脂蛋白（a）水平升高与颈动脉粥样硬化斑块易损性之间的关系：系统综述。

IF 2 4区医学 Q3 NEUROSCIENCES

Journal of Stroke & Cerebrovascular Diseases Pub Date : 2024-09-19 DOI:10.1016/j.jstrokecerebrovasdis.2024.108020

Fernando Garagoli MD, Walter Masson MD, Leandro Barbagelata MD

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引用次数: 0

摘要

背景：脂蛋白（a）[Lp(a)]作为动脉粥样硬化性疾病潜在风险因素的作用已被广泛研究。然而，关于脂蛋白（a）与颈动脉粥样硬化斑块脆弱性之间关系的现有数据却很有限。本系统综述的主要目的是评估脂蛋白（a）水平升高与颈动脉易损斑块特征之间的关系：本系统性综述遵循 PRISMA 指南，进行了全面的文献检索，以确定探讨脂蛋白（a）水平与颈动脉粥样硬化斑块易损性之间关系的研究。实验性或观察性研究均可，不受语言、国家或出版类型的限制：共有 9 项研究（包括 2058 名患者）符合本系统综述的要求。共分析了 5 项横断面研究、3 项前瞻性/回顾性队列研究和 1 项随机对照试验的子分析。两项横断面研究比较了有颈动脉易损斑块和无颈动脉易损斑块患者的脂蛋白（a）水平，结果并不一致。不过，所有根据脂蛋白（a）水平评估颈动脉易损斑块患病率或发病率的研究均显示出正相关性。同样，一项研究发现颈动脉斑块的易损性与脂蛋白（a）水平之间存在显著相关性：本综述分析的几乎所有研究都表明，脂蛋白（a）水平升高与颈动脉易损斑块特征之间存在正相关。然而，还需要进一步的研究来澄清这一问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Association between elevated lipoprotein(a) levels and vulnerability of carotid atherosclerotic plaque: A systematic review

Background

The role of lipoprotein(a) [Lp(a)] as a potential risk factor for atherosclerotic arterial disease has been extensively studied. However, the available data regarding its association with the vulnerability of carotid atherosclerotic plaque is limited. The main objective of the present systematic review was to assess the association between elevated Lp(a) levels and carotid vulnerable plaque features.

Methods

This systematic review adhered to PRISMA guidelines, conducting a comprehensive literature search to identify studies examining the association between Lp(a) levels and vulnerability of carotid atherosclerotic plaque. Experimental or observational studies were eligible, without language, country, or publication type restrictions.

Results

Nine studies including 2058 patients were eligible for this systematic review. Five cross-sectional studies, 3 prospective/retrospective cohorts, and 1 subanalysis of a randomized controlled trial were analyzed. Two cross-sectional studies that compared Lp(a) levels between patients with and without vulnerable carotid plaque showed discordant results. Nevertheless, all the studies that evaluated the prevalence or incidence of vulnerable carotid plaque according to Lp(a) levels showed a positive association. Similarly, one study found a significant correlation between vulnerability of carotid plaque and Lp(a) levels.

Conclusion

Almost all studies analyzed in the present review showed a positive association between elevated Lp(a) levels and carotid vulnerable plaque features. However, further research is needed to clarify this issue.

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来源期刊

Journal of Stroke & Cerebrovascular Diseases Medicine-Surgery

CiteScore

5.00

自引率

4.00%

发文量

583

审稿时长

62 days

期刊介绍： The Journal of Stroke & Cerebrovascular Diseases publishes original papers on basic and clinical science related to the fields of stroke and cerebrovascular diseases. The Journal also features review articles, controversies, methods and technical notes, selected case reports and other original articles of special nature. Its editorial mission is to focus on prevention and repair of cerebrovascular disease. Clinical papers emphasize medical and surgical aspects of stroke, clinical trials and design, epidemiology, stroke care delivery systems and outcomes, imaging sciences and rehabilitation of stroke. The Journal will be of special interest to specialists involved in caring for patients with cerebrovascular disease, including neurologists, neurosurgeons and cardiologists.