[毛茛科植物 C_(20)-二萜生物碱及其生物活性的研究进展]。

Q3 Pharmacology, Toxicology and Pharmaceutics

Zhongguo Zhongyao Zazhi Pub Date : 2024-08-01 DOI:10.19540/j.cnki.cjcmm.20240410.202

Dong-Xu Li, Jie-Kun Xu, Wei-Feng Yin, Fan Zhang, Hai Zhu, Dong-Ge Wang, Kang Ding, Xue-Ge Pan, Ling-Zhi Li, Jun He, Wei-Ku Zhang

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引用次数: 0

摘要

C_(20)-二萜生物碱主要分布于毛茛科乌头属（Aconitum）、白头翁属（Delphinium）和苍耳属（Consolida）的植物中。它们的化学结构主要分为九种类型，如 Atisines、denudatines、hetidines 和 hetisines。生物活性研究表明，C_(20)-二萜生物碱具有卓越的抗肿瘤、镇痛、抗心律失常和抗炎作用。本综述总结了 2002 年至今在毛茛科植物中报道的 190 种 C_(20)-二萜生物碱的化学结构和生物活性，为后续毛茛科植物中 C_(20)-二萜生物碱的研究提供参考。

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[Research progress on C_(20)-diterpenoid alkaloids and their bioactivities in Ranunculaceae].

C_(20)-diterpenoid alkaloids are mainly distributed in plants of genus Aconitum, Delphinium, and Consolida in the Ranunculaceae. Their chemical structures are mainly categorized into nine types such as atisines, denudatines, hetidines, and hetisines. Bioactivity studies have shown that C_(20)-diterpenoid alkaloids have exhibited superior anti-tumor, analgesic, antiarrhythmic, and anti-inflammatory effects. In this review, the chemical structures and biological activities of 190 C_(20)-diterpenoid alkaloids reported in the Ranunculaceae from 2002 to the present were summarized, so as to provide a reference for the subsequent research on C_(20)-diterpenoid alkaloids in plants of Ranunculaceae.

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来源期刊

Zhongguo Zhongyao Zazhi Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

1.50

自引率

0.00%

发文量

581

期刊介绍：