墨西哥人群中亚甲四氢叶酸还原酶 (MTHFR) 多态性与骨肉瘤的关系

IF 1.4 Q3 PEDIATRICS
Irma G Enriquez-Maldonado, Daniel A Montes-Galindo, Rocio Ortiz-Lopez, Jesus Ojeda-Ibarra, Margarita L Martinez-Fierro, Iram P Rodriguez-Sanchez, Augusto Rojas-Martinez, Angel Zavala-Pompa, Carmen Alicia Sanchez-Ramirez, Alejandra E Hernandez-Rangel, Karmina Sanchez-Meza, Idalia Garza-Veloz, Alejandrina Rodriguez-Hernandez, Ivan Delgado-Enciso
{"title":"墨西哥人群中亚甲四氢叶酸还原酶 (MTHFR) 多态性与骨肉瘤的关系","authors":"Irma G Enriquez-Maldonado, Daniel A Montes-Galindo, Rocio Ortiz-Lopez, Jesus Ojeda-Ibarra, Margarita L Martinez-Fierro, Iram P Rodriguez-Sanchez, Augusto Rojas-Martinez, Angel Zavala-Pompa, Carmen Alicia Sanchez-Ramirez, Alejandra E Hernandez-Rangel, Karmina Sanchez-Meza, Idalia Garza-Veloz, Alejandrina Rodriguez-Hernandez, Ivan Delgado-Enciso","doi":"10.3390/pediatric16030066","DOIUrl":null,"url":null,"abstract":"<p><p>The methylenetetrahydrofolate reductase (<i>MTHFR</i>) gene 677C➔T polymorphism is capable of altering folate metabolism and can modify certain neoplasia risk. Reports have suggested that folate can have an influence on bone development and so it is of interest to know if the <i>MTHFR</i> 677C➔T polymorphism is associated with the malignant transformation process of this tissue. The polymorphism was determined in 55 patients with osteosarcoma and in 180 healthy individuals. Compared with C/T+C/C genotypes, a 3.7-fold reduction in osteosarcoma probability is possible with the T/T genotype (OR 0.27, CI 95% 0.07-0.82). Undoubtedly, further studies, utilizing large samples and carried out on different populations, are necessary to confirm these results.</p>","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"16 3","pages":"786-793"},"PeriodicalIF":1.4000,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11417709/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association of Methylenetetrahydrofolate Reductase (<i>MTHFR</i>) Polymorphism with Osteosarcoma in a Mexican Population.\",\"authors\":\"Irma G Enriquez-Maldonado, Daniel A Montes-Galindo, Rocio Ortiz-Lopez, Jesus Ojeda-Ibarra, Margarita L Martinez-Fierro, Iram P Rodriguez-Sanchez, Augusto Rojas-Martinez, Angel Zavala-Pompa, Carmen Alicia Sanchez-Ramirez, Alejandra E Hernandez-Rangel, Karmina Sanchez-Meza, Idalia Garza-Veloz, Alejandrina Rodriguez-Hernandez, Ivan Delgado-Enciso\",\"doi\":\"10.3390/pediatric16030066\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The methylenetetrahydrofolate reductase (<i>MTHFR</i>) gene 677C➔T polymorphism is capable of altering folate metabolism and can modify certain neoplasia risk. Reports have suggested that folate can have an influence on bone development and so it is of interest to know if the <i>MTHFR</i> 677C➔T polymorphism is associated with the malignant transformation process of this tissue. The polymorphism was determined in 55 patients with osteosarcoma and in 180 healthy individuals. Compared with C/T+C/C genotypes, a 3.7-fold reduction in osteosarcoma probability is possible with the T/T genotype (OR 0.27, CI 95% 0.07-0.82). Undoubtedly, further studies, utilizing large samples and carried out on different populations, are necessary to confirm these results.</p>\",\"PeriodicalId\":45251,\"journal\":{\"name\":\"Pediatric Reports\",\"volume\":\"16 3\",\"pages\":\"786-793\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2024-09-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11417709/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pediatric Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3390/pediatric16030066\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/pediatric16030066","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 0

摘要

亚甲基四氢叶酸还原酶(MTHFR)基因 677C➔T 多态性能够改变叶酸代谢,并能改变某些肿瘤的风险。有报告表明,叶酸会对骨骼发育产生影响,因此,了解 MTHFR 677C➔T 多态性是否与该组织的恶性转化过程有关很有意义。我们对 55 名骨肉瘤患者和 180 名健康人进行了多态性测定。与 C/T+C/C 基因型相比,T/T 基因型患骨肉瘤的概率降低了 3.7 倍(OR 0.27,CI 95% 0.07-0.82)。毫无疑问,要证实这些结果,还需要在不同人群中进行大样本的进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of Methylenetetrahydrofolate Reductase (MTHFR) Polymorphism with Osteosarcoma in a Mexican Population.

The methylenetetrahydrofolate reductase (MTHFR) gene 677C➔T polymorphism is capable of altering folate metabolism and can modify certain neoplasia risk. Reports have suggested that folate can have an influence on bone development and so it is of interest to know if the MTHFR 677C➔T polymorphism is associated with the malignant transformation process of this tissue. The polymorphism was determined in 55 patients with osteosarcoma and in 180 healthy individuals. Compared with C/T+C/C genotypes, a 3.7-fold reduction in osteosarcoma probability is possible with the T/T genotype (OR 0.27, CI 95% 0.07-0.82). Undoubtedly, further studies, utilizing large samples and carried out on different populations, are necessary to confirm these results.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Pediatric Reports
Pediatric Reports PEDIATRICS-
CiteScore
2.10
自引率
0.00%
发文量
55
审稿时长
11 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信