乳房内发现淀粉样变性:病例报告

IF 1 Q3 MEDICINE, GENERAL & INTERNAL
Dinh N Nguyen, Abid Qureshi, Michael A Salvian, Phillip Xiao, Cynthia Chen
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引用次数: 0

摘要

背景 淀粉样变性导致细胞外空间沉积β褶状无定形嗜充质蛋白的纤维片。乳腺淀粉样变性是一种罕见病,首例病例于 1973 年报道,此后仅发表过两篇重要的系列病例。这些沉积物可有局部或全身表现,通常单侧出现,但也有双侧受累的病例。一些报道的淀粉样变性病例与乳腺癌有关。病例报告 患者是一名 60 岁的女性,在图像引导下对右侧乳房病灶进行活检后到乳腺外科门诊进行评估。在立体定向引导下进行的核心针活检显示病理与淀粉样蛋白结节性沉积一致,并伴有钙化。显微镜检查显示,脂肪、造口和血管中有细胞外嗜酸性物质沉积。刚果红特殊染色呈阳性。淀粉样蛋白经刚果红特殊染色后,在偏振光下呈现苹果绿双折射。在针刺定位下进行了手术切除,最终的手术病理报告证实了淀粉样蛋白沉积。结论 乳腺淀粉样变性可能具有钙亲和性,会产生巨细胞浸润的异物样反应,并通过导管周围、血管周围或囊内模式分布。导致乳腺淀粉样变性风险增加或与乳腺淀粉样变性相关的一些因素是易患的临床症状,包括自身免疫性疾病、各种乳腺癌和 B 细胞淋巴瘤。乳腺淀粉样变性应根据病因作为原发性或继发性治疗。还需要进一步研究是否有特定的遗传标记使人群易患乳腺淀粉样变性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Amyloidosis Found in the Breast: A Case Report.

BACKGROUND Amyloidosis results in fibrillar sheets of beta-pleated amorphous congophilic protein deposition in the extracellular space. Breast amyloidosis is a rare entity, with the first case reported in 1973 and only 2 major case series published since. These deposits can have local or systemic manifestations and typically present unilaterally, although bilateral involvement has been described. Some reported cases of amyloidosis have been linked to breast cancer. CASE REPORT The patient was a 60-year-old woman who presented to the breast surgery clinic for evaluation after image-guided biopsy of a right breast lesion. Core needle biopsy under stereotactic guidance demonstrated pathology consistent with nodular deposition of amyloid, associated with calcifications. Microscopic examination revealed extracellular deposition of acellular eosinophilic material in fat, stoma, and blood vessels. Congo red special stain was positive. Amyloid with Congo red special stain showed apple green birefringence under polarized light. Surgical excision under needle localization was performed, with the final surgical pathology report confirming amyloid deposits. CONCLUSIONS Breast amyloidosis can have calcium affinity, create a foreign body-like reaction with giant cell infiltration, and distribute through periductal, perivascular, or intralobar patterns. Some factors that can contribute to an increased risk or are associated with breast amyloidosis are predisposing clinical conditions, including autoimmune disease, various breast cancers, and B-cell lymphomas. Amyloidosis of the breast should be treated either as primary or secondary, based on etiology. Further studies need to be conducted on whether there are specific genetic markers that predispose populations to the development of amyloidosis of the breast.

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来源期刊
American Journal of Case Reports
American Journal of Case Reports Medicine-Medicine (all)
CiteScore
1.80
自引率
0.00%
发文量
599
期刊介绍: American Journal of Case Reports is an international, peer-reviewed scientific journal that publishes single and series case reports in all medical fields. American Journal of Case Reports is issued on a continuous basis as a primary electronic journal. Print copies of a single article or a set of articles can be ordered on demand.
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