氯霉素在蛋白质-能量营养不良的年轻恒河猴中的处理。

Drug-nutrient interactions Pub Date : 1986-01-01

B Sharma, S Mehta, C K Nain, V S Mathur

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引用次数: 0

摘要

在三个营养水平下研究了年轻恒河猴对氯霉素的处置:控制、蛋白质能量缺乏和营养康复。在营养不良期，血浆消除半衰期延长，血浆清除率降低。同时，氯霉素特异性udp -葡萄糖醛酸转移酶活性降低。这些变化在营养康复后是可逆的。

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Disposition of chloramphenicol in young rhesus monkeys with protein-energy malnutrition.

The disposition of chloramphenicol was studied in young rhesus monkeys at three levels of nutrition: control, protein-energy deficiency, and following nutritional rehabilitation. During the malnutrition phase, the plasma elimination half-life was prolonged and the plasma clearance was reduced. Simultaneously there was a decrease in the activity of chloramphenicol-specific UDP-glucuronyl transferase. These changes were reversible following nutritional rehabilitation.

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Drug-nutrient interactions

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