胰高血糖素样肽-1 受体激动剂对心功能、运动能力和生活质量的影响

IF 4.2 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Cardiac Failure Review Pub Date : 2024-09-11 eCollection Date: 2024-01-01 DOI:10.15420/cfr.2024.05
Anastasia Shchendrygina, Amina Rakisheva, Ilya Giverts, Yasmin Rustamova, Anzhela Soloveva
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引用次数: 0

摘要

胰高血糖素样肽-1(GLP-1)受体激动剂(RA)是一种新兴的降糖药物,主要用于控制糖尿病和肥胖症。最近,GLP-1 RAs 因其在控制 2 型糖尿病患者血糖之外对心血管的益处而备受关注,表现出以前在钠-葡萄糖共转运体 2 抑制剂的心血管效果试验中出现过的模式,目前已被高度推荐用于治疗心力衰竭(HF)。GLP-1 RAs 在心力衰竭队列中的研究越来越多,但主要是在小规模研究中进行的,这些研究报告对射血分数降低和保留的心力衰竭患者的临床疗效和不同的安全性特征没有得出结论。本综述讨论了 GLP-1 RAs 对不同左心室射血分数的高血压患者的心脏结构和功能、运动能力和生活质量等代偿性高血压预后的影响,以深入了解这些药物在大型临床试验中评估临床预后的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of Glucagon-like Peptide-1 Receptor Agonists on Cardiac Function, Exercise Capacity and Quality of Life.

Glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) are emerging glucose-lowering agents primarily used in managing diabetes and obesity. Recently, GLP-1 RAs have garnered attention for their cardiovascular benefits beyond glycaemic control in patients with type 2 diabetes, exhibiting patterns previously seen in cardiovascular outcomes trials on sodium-glucose cotransporter 2 inhibitors, which now receive a high level of recommendation for the treatment of heart failure (HF). GLP-1 RAs have been increasingly investigated in HF cohorts, but mainly in small-scale studies reporting inconclusive findings regarding clinical outcomes and different safety profiles in HF patients with reduced and preserved ejection fractions. This review discusses the effects of GLP-1 RAs on surrogate HF outcomes, such as cardiac structure and function, exercise capacity and quality of life, in HF patients across the spectrum of left ventricular ejection fraction, to provide insights into the potential of these agents to be investigated in large clinical trials to evaluate clinical outcomes.

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来源期刊
CiteScore
5.60
自引率
0.00%
发文量
31
审稿时长
9 weeks
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