细胞颗粒中的 lncRNAs 景观:洞察它们在癌症中的意义

IF 6.4 2区 生物学 Q1 CELL BIOLOGY
Carolina Mathias, Ana Carolina Rodrigues, Suelen Cristina Soares Baal, Alexandre Luiz Korte de Azevedo, Vanessa Nascimento Kozak, Leticia Ferreira Alves, Jaqueline Carvalho de Oliveira, Sonia Guil, Daniela Fiori Gradia
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引用次数: 0

摘要

通过以膜为基础的区室实现的细胞区隔是细胞生物学的一个基本方面,有助于细胞进化的成功。虽然细胞器历来是研究的重点,但无膜细胞器(MLOs)正逐渐成为关键角色,表现出不同的形态特征和独特的分子组成。最近的研究强调了长非编码 RNA(lncRNA)在 MLOs 中的关键作用,以及它们在不同生物体的各种细胞过程中的参与。就癌症而言,受 lncRNA 表达改变的影响,MLO 形成失调会影响染色质组织、致癌转录、信号通路和端粒延长。这篇综述综述了目前对MLO内lncRNA组成的理解,描述了它们的功能,并探讨了它们的失调是如何导致人类癌症的。肿瘤发生过程中的环境挑战,如营养匮乏和缺氧,会诱导应激颗粒,促进癌细胞的存活和发展。生化技术的进步,尤其是单 RNA 成像方法,为研究活细胞内的 RNA 功能提供了宝贵的工具。然而,由于低丰度 lncRNA 的表达水平有限,检测它们仍然具有挑战性。应探讨lncRNA表达与病理状况(尤其是癌症)之间的相关性,强调单细胞研究对于精确鉴定生物标志物和开发个性化治疗策略的重要性。本文归类于RNA 输出和定位 > RNA 定位 RNA 在疾病和发育中的作用 > RNA 在疾病中的作用 RNA 与蛋白质和其他分子的相互作用 > RNA 蛋白复合物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The landscape of lncRNAs in cell granules: Insights into their significance in cancer.

Cellular compartmentalization, achieved through membrane-based compartments, is a fundamental aspect of cell biology that contributes to the evolutionary success of cells. While organelles have traditionally been the focus of research, membrane-less organelles (MLOs) are emerging as critical players, exhibiting distinct morphological features and unique molecular compositions. Recent research highlights the pivotal role of long noncoding RNAs (lncRNAs) in MLOs and their involvement in various cellular processes across different organisms. In the context of cancer, dysregulation of MLO formation, influenced by altered lncRNA expression, impacts chromatin organization, oncogenic transcription, signaling pathways, and telomere lengthening. This review synthesizes the current understanding of lncRNA composition within MLOs, delineating their functions and exploring how their dysregulation contributes to human cancers. Environmental challenges in tumorigenesis, such as nutrient deprivation and hypoxia, induce stress granules, promoting cancer cell survival and progression. Advancements in biochemical techniques, particularly single RNA imaging methods, offer valuable tools for studying RNA functions within live cells. However, detecting low-abundance lncRNAs remains challenging due to their limited expression levels. The correlation between lncRNA expression and pathological conditions, particularly cancer, should be explored, emphasizing the importance of single-cell studies for precise biomarker identification and the development of personalized therapeutic strategies. This article is categorized under: RNA Export and Localization > RNA Localization RNA in Disease and Development > RNA in Disease RNA Interactions with Proteins and Other Molecules > RNA-Protein Complexes.

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来源期刊
CiteScore
14.80
自引率
4.10%
发文量
67
审稿时长
6-12 weeks
期刊介绍: WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.
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