登革热作为意大利本土传染病：流行病学、临床和病毒学特征。

IF 6.3 3区医学 Q1 INFECTIOUS DISEASES

Travel Medicine and Infectious Disease Pub Date : 2024-09-19 DOI:10.1016/j.tmaid.2024.102762

Serena Vita , Eleonora Lalle , Priscilla Caputi, Francesca Faraglia, Alessandra D'Abramo, Licia Bordi, Gabriella De Carli, Giuseppe Sberna, Maria Letizia Giancola, Gaetano Maffongelli, Cosmina Mija, Andrea Antinori, Stefania Cicalini, Fabrizio Maggi, Enrico Girardi, Francesco Vairo, Emanuele Nicastri

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引用次数: 0

摘要

背景：自2023年8月至11月，意大利共报告了82例本地或与旅行无关的登革热病毒（DENV）感染病例，突显了令人担忧的本地传播趋势。我们描述了罗马大都会地区拉扎罗-斯帕兰扎尼国立传染病研究所收治的10例本地登革热病毒感染者的临床和实验室检查结果：2023 年 8 月至 11 月期间，10 名患者（3 名男性，7 名女性；中位年龄：51 岁）出现典型登革热症状。实验室检测通过 DENV 非结构蛋白 1 和/或免疫球蛋白（IgM/IgG）阳性检测证实了登革热感染，此外还检测到白细胞减少症、血小板减少症和转氨酶升高。一部分患者接受了广泛的生物采样，包括实时 RT-PCR 和免疫荧光，以监测 30 天内的 DENV-RNA 和抗体水平。8 名患者检测到 DENV-1，2 名患者检测到 DENV-3。7 名患者在入院时检测到 IgM 抗体，4 名患者在第 6 天检测到 IgG 抗体。在最初的 8 天内，血液中持续检测到 DENV RNA，但在唾液和尿液中较少见。第 24 天后未检测到 DENV RNA：这些研究结果有助于了解非流行环境中 DENV 感染的临床过程，并将其作为流行病学和临床综合模型，以加强对 DENV 感染的综合征监测和及时诊断。

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Dengue fever as autochthonous infectious disease in Italy: Epidemiological, clinical and virological characteristics

Background

Since August to November 2023, 82 cases of autochthonous or non-travel related Dengue virus (DENV) infection have been reported in Italy, highlighting a concerning trend of local transmission. We describe the clinical and laboratory findings of 10 autochthonous DENV in the metropolitan area of Rome admitted to the Lazzaro Spallanzani National Institute for Infectious Diseases.

Method and results

Ten patients (3 males, 7 females; median age: 51) with classic dengue fever symptoms were admitted between August and November 2023. Laboratory tests confirmed dengue infection through DENV non-structural protein 1 and/or immunoglobulins (IgM/IgG) positive tests, moreover leukopenia, thrombocytopenia, elevated transaminases were detected. A subset of patients underwent extensive biological sampling, including real-time RT-PCR and immunofluorescence, to monitor DENV-RNA and antibody levels over 30 days. DENV-1 was detected in 8 patients and DENV-3 in 2. Upon admission specific IgM antibodies were found in 7 patients while IgG antibodies in 4 patients. DENV RNA was consistently detected in blood within the first 8 days but was less common in saliva and urine. No DENV RNA was detected after day 24.

Conclusion

These findings contribute to the understanding of the clinical course of DENV infection in a non-endemic setting as integrated epidemiological and clinical model to increase syndromic surveillance and timely diagnosis of DENV infections.

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来源期刊

Travel Medicine and Infectious Disease PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-INFECTIOUS DISEASES

CiteScore

19.40

自引率

1.70%

发文量

211

审稿时长

49 days

期刊介绍： Travel Medicine and Infectious Disease Publication Scope: Publishes original papers, reviews, and consensus papers Primary theme: infectious disease in the context of travel medicine Focus Areas: Epidemiology and surveillance of travel-related illness Prevention and treatment of travel-associated infections Malaria prevention and treatment Travellers' diarrhoea Infections associated with mass gatherings Migration-related infections Vaccines and vaccine-preventable disease Global policy/regulations for disease prevention and control Practical clinical issues for travel and tropical medicine practitioners Coverage: Addresses areas of controversy and debate in travel medicine Aims to inform guidelines and policy pertinent to travel medicine and the prevention of infectious disease Publication Features: Offers a fast peer-review process Provides early online publication of accepted manuscripts Aims to publish cutting-edge papers