ZDHHC13/ZDHHC17 亚家族：从生物功能到疾病治疗靶点。

IF 9.1 2区医学 Q1 PHARMACOLOGY & PHARMACY

Pharmacological research Pub Date : 2024-09-19 DOI:10.1016/j.phrs.2024.107418

Ying Zhang , Sisi Fan , Lu He , Lanfang Li

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引用次数: 0

摘要

ZDHHC13/ZDHHC17 亚家族属于含锌手指 DHHC-domain（ZDHHC）家族，包括 ZDHHC13 和 ZDHHC17。最近的研究表明，ZDHHC13/ZDHHC17 亚家族参与了多种病理和生理过程，包括 S-棕榈酰化、Mg2+ 转运和 CALCOCO1 介导的 Golgiphagy。此外，ZDHHC13/ZDHHC17 亚家族在亨廷顿病（HD）、骨质疏松症、特应性皮炎、糖尿病和癌症等多种疾病的发生和发展中起着至关重要的作用。在本综述中，我们描述了 ZDHHC13/ZDHHC17 亚家族的分布、结构和翻译后修饰（PTMs）。此外，我们还有效总结了该亚家族的生物学功能和相关疾病。鉴于 ZDHHC13/ZDHHC17 亚家族的多变性，我们有必要对其成员进行进一步的研究，以了解相关的病理生理学机制，并制定管理和控制各种疾病的策略。

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The ZDHHC13/ZDHHC17 subfamily: From biological functions to therapeutic targets of diseases

The ZDHHC13/ZDHHC17 subfamily belongs to the zinc finger DHHC-domain containing (ZDHHC) family, including ZDHHC13 and ZDHHC17. Recent studies have shown that the ZDHHC13/ZDHHC17 subfamily is involved in various pathological and physiological processes, including S-palmitoylation, Mg²⁺ transport, and CALCOCO1-mediated Golgiphagy. Moreover, the ZDHHC13/ZDHHC17 subfamily plays a crucial role in the occurrence and development of many diseases, including Huntington disease (HD), osteoporosis, atopic dermatitis, diabetes, and cancer. In the present review, we describe the distribution, structure, and post-translational modifications (PTMs) of the ZDHHC13/ZDHHC17 subfamily. Moreover, we effectively summarize the biological functions and associated diseases of this subfamily. Given the pleiotropy of the ZDHHC13/ZDHHC17 subfamily, it is imperative to conduct further research on its members to comprehend the pertinent pathophysiological mechanisms and to devise tactics for managing and controlling various diseases.

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来源期刊

Pharmacological research 医学-药学

CiteScore

18.70

自引率

3.20%

发文量

491

审稿时长

8 days

期刊介绍： Pharmacological Research publishes cutting-edge articles in biomedical sciences to cover a broad range of topics that move the pharmacological field forward. Pharmacological research publishes articles on molecular, biochemical, translational, and clinical research (including clinical trials); it is proud of its rapid publication of accepted papers that comprises a dedicated, fast acceptance and publication track for high profile articles.