Lara-Cano R, Castañeda-Méndez P F, Uribe-Esquivel M, Barbero-Becerra V J
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引用次数: 0
摘要
肝血吸虫病是一种被忽视的寄生虫病,每年影响全球数百万人,导致高昂的医疗费用以及受感染者发病率和死亡率的增加。人们已对这种疾病的病理生理学进行了广泛研究;因此,现在人们对导致肝损伤并进而发展为肝纤维化的信号通路有了更深入的了解。研究阐明了可溶性卵抗原在肝肉芽肿和肝纤维化发展中的作用、转录信号转导和激活因子 3 及其在肝损伤中的参与、热休克蛋白 47 的作用及其在肝纤维化中的参与、白细胞介素-37 的抗炎作用以及自然杀伤细胞和自然杀伤 T 细胞在疾病发展中的作用。肝血吸虫病可从单纯的肝肿大发展到门静脉高压合并肝纤维化。就诊断而言,对排泄物进行显微镜检查仍是金标准;但最近,腹部超声波在评估寄生虫引起的肝脏病变方面发挥了重要作用。吡喹酮被认为是首选的治疗药物,具有潜在的预防性抗纤维化作用。
Hepatic schistosomiasis as a determining factor in the development of hepatic granulomas and liver fibrosis: a review of the current literature.
Hepatic schistosomiasis is a neglected parasitosis that affects millions of people each year worldwide and leads to high healthcare costs and increased morbidity and mortality in infected humans. It is a disease that has been widely studied in terms of its pathophysiology; therefore, the signaling pathways that lead to liver damage, with the consequent development of liver fibrosis, are now better understood. Research has elucidated the role of soluble egg antigen in the development of hepatic granulomas and liver fibrosis, the signal transducer and activator of transcription 3 and its participation in liver damage, the role of heat shock protein 47 and its involvement in liver fibrosis, the anti-inflammatory effects caused by interleukin-37, and the role of natural killer and natural killer T cells in the development of the disease. Hepatic schistosomiasis can range from simple hepatomegaly to the development of portal hypertension combined with hepatic fibrosis. For diagnostic purposes, a microscopic examination of excreta remains the gold standard; however, abdominal ultrasound has recently taken on an important role in the assessment of liver lesions produced by the parasite. Praziquantel is considered the management drug of choice, and has been associated with a potential preventive antifibrotic effect.
期刊介绍:
Pathogens and Global Health is a journal of infectious disease and public health that focuses on the translation of molecular, immunological, genomics and epidemiological knowledge into control measures for global health threat. The journal publishes original innovative research papers, reviews articles and interviews policy makers and opinion leaders on health subjects of international relevance. It provides a forum for scientific, ethical and political discussion of new innovative solutions for controlling and eradicating infectious diseases, with particular emphasis on those diseases affecting the poorest regions of the world.