Ladislav Klena, Kristina Galvankova, Adela Penesova, Olga Krizanova
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引用次数: 0
摘要
维生素 D 是一种重要的类固醇激素,具有免疫调节作用,能控制钙和磷的平衡,并对人体健康产生重大影响。维生素 D 缺乏症是一个全球性的健康问题,影响着全球约 60% 的成年人,并与癌症等一系列不同类型的疾病有关。维生素 D 参与细胞增殖、分化、能量代谢和不同类型细胞死亡(如细胞凋亡、自噬等)的调节。在生理条件下,它还能调节免疫反应、血管生成等与癌症有关的基本过程。缺乏维生素 D 会增加罹患某些类型癌症的风险,如结直肠癌、乳腺癌、卵巢癌、前列腺癌、胰腺癌等。维生素 D 在癌症预防、致癌和治疗中的作用仍在研究中,并取决于癌症的类型。本综述总结了维生素 D 在上述三个方面的作用,并讨论了维生素 D 在癌症治疗中的作用机制和潜在可能性。
Vitamin D supplementation in cancer prevention and the management of cancer therapy.
Vitamin D is an important steroid hormone that exerts immunomodulatory actions, controls calcium and phosphate homeostasis, and significantly affects human health. Vitamin D deficiency is a global health problem, affecting approximately 60% of adults worldwide, and has been implicated in a range of different types of diseases, e.g., cancer. Vitamin D is involved in the regulation of cell proliferation, differentiation, energetic metabolism, and different types of cell death (e.g., apoptosis, autophagy, etc.). In physiological conditions, it is also able to modulate immune responses, angiogenesis, etc., which belongs to fundamental cancer-related processes. Vitamin D deficiency has been associated with an increased risk of some types of cancer, e.g., colorectal, breast, ovarian, prostate, pancreatic, etc. The role of vitamin D in cancer prevention, carcinogenesis, and cancer treatment is still under investigation and depends on the type of cancer. This review summarizes the role of vitamin D in all three above-mentioned aspects and discusses the mechanism of action and potential possibilities in cancer treatment.