非编码 RNA 在多发性骨髓瘤中的作用。

IF 2.1 4区医学 Q3 HEMATOLOGY

Leukemia research Pub Date : 2024-09-17 DOI:10.1016/j.leukres.2024.107593

Ming Lei , Juan Liang , Kaiyun Guo , Langui Tang , Yuxing He , Xuefeng Wu

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引用次数: 0

摘要

非编码 RNA（ncRNA）是细胞内的一类核酸分子，它们不编码蛋白质，但在调节基因表达、维持细胞稳态和介导细胞信号传导方面发挥着重要作用。这类核酸分子包括微小核糖核酸（miRNA）、长非编码核糖核酸（lncRNA）、转移核糖核酸（tRNA）、环状核糖核酸（circRNA）、小干扰核糖核酸（siRNA）等。在癌症组织中，lncRNAs 的异常表达已被证实，这意味着它们参与了癌变或肿瘤抑制过程。此外，circRNA 通过调节相关基因的表达影响肿瘤的病情发展，而 siRNA 在诱导细胞凋亡的同时还能抑制肿瘤细胞的增殖、侵袭和转移。本综述将阐明 ncRNA 在多发性骨髓瘤（MM）中的生物学功能，并探讨其作为治疗靶点的潜在价值。

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Roles of noncoding RNAs in multiple myeloma

Noncoding RNAs (ncRNAs) constitute a class of nucleic acid molecules within cells that do not encode proteins but play important roles in regulating gene expression, maintaining cellular homeostasis, and mediating cell signaling. This class encompasses microRNAs (miRNAs), long noncoding RNAs (lncRNAs), transfer RNAs (tRNAs), circular RNAs (circRNAs), small interfering RNAs (siRNAs), and others. miRNAs are pivotal in the regulation of gene expression in hematologic malignancies. Aberrant expression of lncRNAs has been confirmed in cancerous tissues, implicating their involvement in carcinogenesis or tumor suppression processes. tRNAs may induce errors or disturbances in protein synthesis, thereby affecting normal cellular function and proliferation. Moreover, circRNAs influence disease progression in tumors by modulating the expression of relevant genes, and siRNAs can inhibit tumor cell proliferation, invasion, and metastasis while inducing apoptosis. This review will elucidate the biological functions of ncRNAs in multiple myeloma (MM) and explore their potential value as therapeutic targets.

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来源期刊

Leukemia research 医学-血液学

CiteScore

4.00

自引率

3.70%

发文量

259

审稿时长

1 months

期刊介绍： Leukemia Research an international journal which brings comprehensive and current information to all health care professionals involved in basic and applied clinical research in hematological malignancies. The editors encourage the submission of articles relevant to hematological malignancies. The Journal scope includes reporting studies of cellular and molecular biology, genetics, immunology, epidemiology, clinical evaluation, and therapy of these diseases.