COVID-19并发严重M1UK系化脓性链球菌感染的老年患者：两个病例的报告。

IF 4.8 2区医学 Q1 INFECTIOUS DISEASES

International Journal of Infectious Diseases Pub Date : 2024-09-19 DOI:10.1016/j.ijid.2024.107246

Ae Kawaguchi , Kentaro Nagaoka , Hitoshi Kawasuji , Toshiomi Kawagishi , Takamasa Fuchigami , Kaho Ikeda , Jun-Ichi Kanatani , Tomoaki Doi , Kazunori Oishi , Yoshihiro Yamamoto

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引用次数: 0

摘要

病例 1：一名 71 岁的男性因渐进性发热和呼吸困难被送入我院，发病三天后出现 COVID-19。初步胸部计算机断层扫描（CT）显示肺部病变与继发性细菌感染一致。从气管插管采集的原发痰培养物中分离出化脓性链球菌，并确定为致病微生物。病例 2：一名 91 岁的老人在 COVID-19 发病 9 天后因严重低血压转入我院。胸部 CT 显示心包积液，心包穿刺术发现脓性积液。从液体标本中分离出了化脓性链球菌，并确定其为继发性细菌性心包炎的致病微生物。随后，通过基因分析确定这两名患者的分离物均为 M1UK 系的化脓性链球菌。该报告表明，COVID-19 是经呼吸道感染严重 M1UK 的潜在风险因素。

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COVID-19 complicated with severe M1UK-lineage Streptococcus pyogenes infection in elderly patients: A report of two cases

Case 1: A 71-year-old man was admitted to our hospital with progressive fever and dyspnea, which had developed three days after the onset of COVID-19. Initial chest computed tomography (CT) revealed a pulmonary lesion consistent with a secondary bacterial infection. Streptococcus pyogenes was isolated from cultures of primary sputum collected from the endotracheal tube, and identified as the causative microorganism. Case 2: A 91-year-old man was transferred to our hospital with severe hypotension, which had developed nine days after the onset of COVID-19. A chest CT revealed pericardial effusion and pericardiocentesis yielded purulent fluid. S. pyogenes was isolated from the fluid specimens and was identified as the causative microorganism of the secondary bacterial pericarditis. Isolates from both patients were subsequently identified as M1_UK-lineage S. pyogenes via genetic analysis. This report implicates COVID-19 as a potential risk factor for severe M1_UK infection via the respiratory tract.

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来源期刊

International Journal of Infectious Diseases 医学-传染病学

CiteScore

18.90

自引率

2.40%

发文量

1020

审稿时长

30 days

期刊介绍： International Journal of Infectious Diseases (IJID) Publisher: International Society for Infectious Diseases Publication Frequency: Monthly Type: Peer-reviewed, Open Access Scope: Publishes original clinical and laboratory-based research. Reports clinical trials, reviews, and some case reports. Focuses on epidemiology, clinical diagnosis, treatment, and control of infectious diseases. Emphasizes diseases common in under-resourced countries.