{"title":"作为抗疟疾剂的有机碲（IV）复合物：合成、表征和计算见解。","authors":"Anisha Bhardwaj, Amit Dubey, Aisha Tufail, Nasir Tufail, Manish Kumar, Sapana Garg","doi":"10.1080/17568919.2024.2401310","DOIUrl":null,"url":null,"abstract":"<p><p><b>Aim:</b> To synthesize and evaluate the antimalarial and antioxidant activities of novel organotellurium (IV) thiophene-based complexes.<b>Materials & methods:</b> Synthesized complexes were characterized using NMR, IR and mass spectrometry. Their biological activities were assessed using <i>in vitro</i> assays and molecular docking studies.<b>Results:</b> The complexes exhibited significant antimalarial activity against <i>Plasmodium falciparum</i>, with the highest activity observed for complexes 5b and 5e. ADMET properties confirmed their potential as therapeutic agents.</p>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Organotellurium (IV) complexes as anti-malarial agents: synthesis, characterization and computational insights.\",\"authors\":\"Anisha Bhardwaj, Amit Dubey, Aisha Tufail, Nasir Tufail, Manish Kumar, Sapana Garg\",\"doi\":\"10.1080/17568919.2024.2401310\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Aim:</b> To synthesize and evaluate the antimalarial and antioxidant activities of novel organotellurium (IV) thiophene-based complexes.<b>Materials & methods:</b> Synthesized complexes were characterized using NMR, IR and mass spectrometry. Their biological activities were assessed using <i>in vitro</i> assays and molecular docking studies.<b>Results:</b> The complexes exhibited significant antimalarial activity against <i>Plasmodium falciparum</i>, with the highest activity observed for complexes 5b and 5e. ADMET properties confirmed their potential as therapeutic agents.</p>\",\"PeriodicalId\":3,\"journal\":{\"name\":\"ACS Applied Electronic Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2024-09-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Electronic Materials\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/17568919.2024.2401310\",\"RegionNum\":3,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, ELECTRICAL & ELECTRONIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Electronic Materials","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/17568919.2024.2401310","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}
引用次数: 0
摘要
目的：合成并评估新型有机碲（IV）噻吩基复合物的抗疟和抗氧化活性：使用核磁共振、红外和质谱对合成的复合物进行表征。材料与方法：利用核磁共振、红外光谱和质谱对合成的复合物进行了表征，并利用体外试验和分子对接研究对其生物活性进行了评估：结果：复合物对恶性疟原虫具有明显的抗疟活性，其中复合物 5b 和 5e 的活性最高。ADMET 特性证实了它们作为治疗剂的潜力。
Organotellurium (IV) complexes as anti-malarial agents: synthesis, characterization and computational insights.
Aim: To synthesize and evaluate the antimalarial and antioxidant activities of novel organotellurium (IV) thiophene-based complexes.Materials & methods: Synthesized complexes were characterized using NMR, IR and mass spectrometry. Their biological activities were assessed using in vitro assays and molecular docking studies.Results: The complexes exhibited significant antimalarial activity against Plasmodium falciparum, with the highest activity observed for complexes 5b and 5e. ADMET properties confirmed their potential as therapeutic agents.
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