衰老对人体皮肤肥大细胞密度的影响:光暴露区和光保护区的对比分析。

IF 1.2 4区 医学 Q3 ANATOMY & MORPHOLOGY
Snezana Lestarevic, Sladjana Savic, Mirjana Dejanovic, Milica Mijovic, Predrag Mandic, Dragan Marjanovic, Milan Filipovic, Ivan Branimira Rancic, Teodora Jorgacevic
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引用次数: 0

摘要

背景:肥大细胞是源自骨髓的单核细胞。肥大细胞能产生各种生物活性物质,从而积极参与与内在和外在皮肤老化相关的免疫和炎症过程。本研究重点关注肥大细胞在皮肤老化不同阶段健康皮肤中的分布和密度:该项目包括从 90 名年龄在 0-82 岁之间的尸体中获取的光暴露和光保护皮肤样本。样本被分为五个年龄组:新生儿、青年、中年、老年和高龄。为了观察肥大细胞,我们采用了多种组织化学染色方案:结果:受光照射皮肤的肥大细胞数量与个体年龄有明显相关性。一般来说,年轻组与年长组相比,受光照保护皮肤的肥大细胞数量在统计学上明显较低;但是,受光照保护皮肤的肥大细胞密度与年龄的相关性在统计学上并不显著。在中年、老年和最年长的年龄组中,与光保护区域相比,光暴露区域皮肤中的肥大细胞数量明显较高:结论:肥大细胞密度的增加仅与光暴露皮肤的年龄有关。与年龄相关的真皮肥大细胞在光暴露皮肤中的高积累可能是光老化过程中的一个重要因素,也是导致皮肤癌发生的一个因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effect of aging on mast cell density in human skin: a comparative analysis of photoexposed and photoprotected regions.

Background: Mast cells are mononuclear cells originating from bone marrow. They produce various biologically active substances, which allow them to actively participate in immune and inflammatory processes associated with intrinsic and extrinsic skin aging. This research focused on distribution and density of mast cells in healthy skin in different stages of skin aging.

Material and methods: This project included samples of photoexposed and photoprotected skin, obtained from 90 cadavers aged 0-82 years. The samples were classified into five age groups: newborns, young age, middle age, senior age and the oldest age. In order to visualize the mast cells, we have employed several histochemical staining protocols.

Results: The number of mast cells of the photoexposed skin significantly correlated to the individual's age. The number of mast cells of the photoprotected skin was in general statistically significantly lower in younger compared to older groups; however, the correlation of the mast cell density in photoprotected skin and the age did not reach statistical significance. In middle age, senior age and the oldest age groups, a significantly higher number of mast cells was recorded in the skin of the photoexposed compared to photoprotected region.

Conclusions: The increase in mast cell density correlated with age only in photoexposed skin. Age-related higher accumulation of dermal mast cells in photoexposed skin can be an important factor in the photoaging process, as well as the contributing factor in the occurrence of skin cancer.

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来源期刊
Folia morphologica
Folia morphologica ANATOMY & MORPHOLOGY-
CiteScore
2.40
自引率
0.00%
发文量
218
审稿时长
6-12 weeks
期刊介绍: "Folia Morphologica" is an official journal of the Polish Anatomical Society (a Constituent Member of European Federation for Experimental Morphology - EFEM). It contains original articles and reviews on morphology in the broadest sense (descriptive, experimental, and methodological). Papers dealing with practical application of morphological research to clinical problems may also be considered. Full-length papers as well as short research notes can be submitted. Descriptive papers dealing with non-mammals, cannot be accepted for publication with some exception.
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