可能由特比萘芬和/或伊曲康唑诱发的血管炎--一项病例研究。

IF 1.1 Q4 PHARMACOLOGY & PHARMACY
Sahil Kumar, Swetha Narayanan, Prasan Kumar Panda, Arnab Chowdhury
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引用次数: 0

摘要

导言:在将皮肤/系统血管炎归咎于药物使用之前,必须排除其他病因,如自身免疫性疾病和细菌感染:本报告讨论了一名年轻男子的病例,他在使用抗真菌药物(特比萘芬和伊曲康唑)治疗皮肤癣菌感染后出现多器官衰竭和皮肤血管炎。自身免疫性疾病和感染的检测结果均为阴性。考虑到他的用药史和皮肤活检显示的白细胞坏死性脉管炎,推断脉管炎很可能是药物引起的。尽管接受了类固醇、静脉注射免疫球蛋白和血浆置换治疗,但患者仍未能存活,这可能是由于诊断和治疗延误所致:结论:在社区实践中,药物诱发的脉管炎(DIV)经常被忽视。当患者出现皮疹、发热和多器官功能障碍时,应考虑 DIV,尤其是近期使用过药物的患者。非处方抗真菌药(如特比萘芬或伊曲康唑)可导致 DIV,如果不及时诊断和治疗,可能会致命。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Possible Terbinafine and/or Itraconazole Induced Vasculitis - A Case Study.

Introduction: It is essential to exclude other causes, such as autoimmune diseases and bacterial infections, before attributing cutaneous/systemic vasculitis to drug use.

Case study: This report discusses the case of a young man who developed multi-organ failure and cutaneous vasculitis following the use of antifungal medications (terbinafine and itraconazole) for dermatophyte infections. Tests for autoimmune diseases and infections were negative. Given his drug history and a skin biopsy indicating leukocytoclastic vasculitis, it was inferred that the vasculitis was likely drug-induced. Despite treatment with steroids, intravenous immunoglobulins, and plasmapheresis, the patient did not survive, possibly due to delayed diagnosis and treatment.

Conclusion: In community practice, Drug-induced Vasculitis (DIV) is frequently overlooked. When patients present with skin rash, fever, and multi-organ dysfunction, DIV should be considered, particularly in the context of recent drug use. Over-the-counter antifungals, like terbinafine or itraconazole, can cause DIV and may be fatal if not promptly diagnosed and treated.

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来源期刊
Current drug safety
Current drug safety PHARMACOLOGY & PHARMACY-
CiteScore
2.10
自引率
0.00%
发文量
112
期刊介绍: Current Drug Safety publishes frontier articles on all the latest advances on drug safety. The journal aims to publish the highest quality research articles, reviews and case reports in the field. Topics covered include: adverse effects of individual drugs and drug classes, management of adverse effects, pharmacovigilance and pharmacoepidemiology of new and existing drugs, post-marketing surveillance. The journal is essential reading for all researchers and clinicians involved in drug safety.
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