转移性黑色素瘤:急性肝功能衰竭的意外病因。

IF 0.8 Q4 GASTROENTEROLOGY & HEPATOLOGY
Clinical Journal of Gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-09-17 DOI:10.1007/s12328-024-02039-1
Robert S O'Neill, Phillip Leaver, Connor Ryan, Sharron Liang, Santosh Sanagapalli, Rasha Cosman
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引用次数: 0

摘要

继发于转移性黑色素瘤的急性肝功能衰竭极为罕见,文献报道也仅限于病例。这种疾病本身症状模糊,因此在没有高度临床怀疑的情况下很难诊断。此外,转移性黑色素瘤继发急性肝功能衰竭的预后也不容乐观。本病例是一名 59 岁的男性,既往有切除皮肤黑色素瘤的远期病史,因腹痛和肝酶失调而到我院就诊,提示急性肝炎。由于肝功能进行性失常,横断面影像学检查提示为浸润性病因,因此对左侧腋窝淋巴结进行了活检,结果显示为转移性黑色素瘤。患者随后病情恶化,陷入急性肝功能衰竭,尽管对其潜在的转移性黑色素瘤进行了急性治疗,但仍在初次发病后 17 天死亡。本病例强调了急性肝衰竭的一个不常见病因,以及继发于转移性黑色素瘤的急性肝衰竭的不良预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Metastatic melanoma: an unexpected cause of acute liver failure.

Acute liver failure secondary to metastatic melanoma is exceedingly rare with the literature limited to case reports. The disease itself presents with vague symptoms making diagnosis difficult without a high clinical suspicion. Further to this, the prognosis of acute liver failure secondary to metastatic melanoma is dismal. We present the case of a 59-year-old male with a distant history of previously excised cutaneous melanoma who presented to our institution with abdominal pain and liver enzyme derangement suggestive of acute hepatitis. Due to progressive derangement in liver function and cross-sectional imaging suggestive of an infiltrative cause, a left axillary lymph node was biopsied which demonstrated metastatic melanoma. The patient subsequently deteriorated into acute liver failure and despite acute treatment of his underlying metastatic melanoma died 17 days post initial presentation. This case highlights an uncommon cause of acute liver failure as well as the poor prognosis associated with acute liver failure secondary to metastatic melanoma.

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来源期刊
Clinical Journal of Gastroenterology
Clinical Journal of Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
2.00
自引率
0.00%
发文量
182
期刊介绍: The journal publishes Case Reports and Clinical Reviews on all aspects of the digestive tract, liver, biliary tract, and pancreas. Critical Case Reports that show originality or have educational implications for diagnosis and treatment are especially encouraged for submission. Personal reviews of clinical gastroenterology are also welcomed. The journal aims for quick publication of such critical Case Reports and Clinical Reviews.
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