澳大利亚北部地区计算机断层扫描冠状动脉造影中冠状动脉疾病的患病率和负担及其与高密度脂蛋白的相关性。

IF 2.1 3区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Cardiovascular diagnosis and therapy Pub Date : 2024-08-31 Epub Date: 2024-08-05 DOI:10.21037/cdt-23-458
Angus A W Baumann, Ross L Roberts-Thomson, Rushab Shah, Guy F Reynolds, James Marangou, Hussam Tayeb, Peter J Psaltis, Alex Brown, Dennis Wong, Nadarajah Kangaharan, Marcus Ilton
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引用次数: 0

摘要

众所周知,澳大利亚土著居民的冠状动脉疾病(CAD)发病率高于非土著居民。血清中高密度脂蛋白(HDL)含量低、血清甘油三酯含量高的致动脉粥样硬化血脂特征在澳大利亚土著人中更为普遍。使用计算机断层扫描冠状动脉造影术(CTCA)进行风险分层和诊断冠状动脉粥样硬化症(CAD)已在中度风险人群中得到验证,但在澳大利亚土著居民等特定高风险人群中的数据却很有限。通过对患者记录的回顾性研究,我们旨在确认在澳大利亚北部地区接受 CTCA 检查的澳大利亚土著居民是否存在致动脉粥样硬化的血脂谱,如果存在,这是否与 CAD 的患病率或负担相关。我们的研究表明,澳大利亚原住民在接受 CTCA 检查时的 CAD 患病率(52.6% vs. 50.3%,P=0.80)和负担(Leaman 评分 6.03±4.66 vs. 6.96±4.82,P=0.44)与非原住民患者相似,但年龄小 8 岁(41.9±8.9 vs. 50.0±11.9岁,Pvs 1.09±0.35 vs. 1.18±0.36mmol/L,P=0.009)。未来的临床指南应考虑 CTCA 在澳大利亚土著居民中的作用,以及年轻患者是否能从中受益。过早患上冠状动脉粥样硬化的原因,包括致动脉粥样硬化的血脂状况,需要我们持续关注,以实现澳大利亚土著居民和非土著居民心血管疾病治疗结果的公平性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prevalence and burden of coronary artery disease on computed tomography coronary angiography and its correlation with high-density lipoprotein in the Northern Territory, Australia.

Indigenous Australians are known to have a higher prevalence of coronary artery disease (CAD) than non-Indigenous counterparts. Atherogenic lipid profiles, characterised by low serum levels of high-density lipoprotein (HDL) and higher serum triglycerides, have been shown to be more prevalent in Indigenous Australians. The use of computed tomography coronary angiography (CTCA) for risk stratification and diagnosis of CAD has been validated in moderate risk populations, but limited data exists in specific high-risk populations such as Indigenous Australians. Through a retrospective study of patient records, we aimed to confirm if an atherogenic lipid profile occurred in Indigenous Australians undergoing CTCA in the Northern Territory of Australia and if so, whether this correlated with the prevalence or burden of CAD. We demonstrate that Indigenous Australians have similar prevalence (52.6% vs. 50.3%, P=0.80) and burden of CAD (Leaman score 6.03±4.66 vs. 6.96±4.82, P=0.44) on CTCA as non-Indigenous patients, but were 8 years younger (41.9±8.9 vs. 50.0±11.9 years, P<0.001) at the time of examination. We confirmed the presence of an atherogenic lipid profile in Indigenous patients and showed low serum-HDL was associated with very premature (patients aged 18-35 years) CAD in comparison to premature (patients aged 36-55 years) and mature-onset (patients aged 56 years and older) CAD (0.71±0.25 vs. 1.09±0.35 vs. 1.18±0.36 mmol/L, P=0.009). Future clinical guidelines should consider the role of CTCA in Indigenous Australians and whether younger patients may benefit. The causes of premature CAD, including atherogenic lipid profiles, require an ongoing focus in order to achieve equitable cardiovascular outcomes for Indigenous and non-Indigenous Australians.

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来源期刊
Cardiovascular diagnosis and therapy
Cardiovascular diagnosis and therapy Medicine-Cardiology and Cardiovascular Medicine
CiteScore
4.90
自引率
4.20%
发文量
45
期刊介绍: The journal ''Cardiovascular Diagnosis and Therapy'' (Print ISSN: 2223-3652; Online ISSN: 2223-3660) accepts basic and clinical science submissions related to Cardiovascular Medicine and Surgery. The mission of the journal is the rapid exchange of scientific information between clinicians and scientists worldwide. To reach this goal, the journal will focus on novel media, using a web-based, digital format in addition to traditional print-version. This includes on-line submission, review, publication, and distribution. The digital format will also allow submission of extensive supporting visual material, both images and video. The website www.thecdt.org will serve as the central hub and also allow posting of comments and on-line discussion. The web-site of the journal will be linked to a number of international web-sites (e.g. www.dxy.cn), which will significantly expand the distribution of its contents.
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