西藏昌都地区察雅县肺动脉高压患者临床特征分析

IF 2.1 3区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Cardiovascular diagnosis and therapy Pub Date : 2024-08-31 Epub Date: 2024-08-15 DOI:10.21037/cdt-23-486
Ruimin Dong, Xing Shui, Juan Zhang, Zhu Dun
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引用次数: 0

摘要

背景:肺动脉高压(PH)是以肺动脉高血压为特征的严重健康问题,但有关其在藏族人口中临床特征的数据有限。本研究旨在探讨居住在西藏昌都地区察雅县的藏族人群中肺动脉高压患者的临床特征:这是一项回顾性横断面研究。共纳入2019年3月至2020年10月期间在中国西藏昌都市察雅县人民医院内科通过超声心动图确诊的94名PH患者。此外,还选取了52名非PH住院患者作为对照组。对患者病历中的人口统计学和临床数据、实验室结果和超声心动图结果进行了审查。采用PH组和对照组之间的学生t检验/卡方检验、对照组和PH亚组之间的单因素方差分析(ANOVA)、皮尔逊相关系数和斯皮尔曼相关系数对结果进行分析:在内科的 1,689 名住院病人中,有 94 人被确定为 PH 患者,并进行了分析。PH 患者的平均血红蛋白水平(150.64±21.67 g/L)与高海拔地区正常人群的血红蛋白水平(146.65±17.51 g/L)相似(P=0.28)。观察到肝功能指标异常,51.06%的 PH 患者表现为高尿酸血症(Pvs.43.67±3.40 fL,Pvs.13.52%±1.32%,Pvs.(256.63±72.85)×109/L]。此外,与右心功能相关的超声心动图指标与红细胞计数、胆红素、白蛋白、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇存在相关性(多重显著相关系数r,幅度在0.22至0.54之间):慢性肺部疾病和左心疾病是高海拔地区藏族患者 PH 的常见病因。结论:慢性肺部疾病和左心疾病是高海拔地区藏族 PH 患者的常见病因,高海拔地区藏族 PH 患者的多项肝功能和代谢指标出现异常变化,这些变化与心脏超声观察到的形态指标相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Analysis of clinical characteristics of patients with pulmonary hypertension in Chaya County, Chamdo, Tibet.

Background: Pulmonary hypertension (PH) is a critical health issue marked by high blood pressure in the pulmonary arteries, with limited data on its clinical characteristics in the Tibetan population. The objective of this study was to examine the clinical characteristics of PH patients among Tibetan population residing in Chaya County, Changdu, Tibet.

Methods: This was a retrospective cross-sectional study. A total of 94 PH patients diagnosed via echocardiography at the Internal Medicine Department of Chaya County People's Hospital in Changdu (Tibet, China) between March 2019 and October 2020 were included. Additionally, 52 non-PH inpatients were selected as the control group. Patient medical records were reviewed for demographic and clinical data, lab results, and echocardiographic findings. Student's t-test/chi-squared test between PH and control group, one-way analysis of variance (ANOVA) among control and PH subgroups, Pearson's and Spearman's correlation coefficient were used to analysis the results.

Results: Out of 1,689 inpatients in the Internal Medicine Department, 94 were identified as PH patients for analysis. The average hemoglobin level among PH patients (150.64±21.67 g/L) was similar to that observed in the normal population (146.65±17.51 g/L) at high altitude (P=0.28). Abnormal liver function indexes were observed, with 51.06% of PH patients exhibiting hyperuricemia (P<0.001 compared to control's 15.38%). The PH group demonstrated significantly elevated red blood cell distribution width (RDW)-standard deviation (50.59±6.49 vs. 43.67±3.40 fL, P<0.001) and RDW-coefficient of variation of (16.18%±3.04% vs. 13.52%±1.32%, P<0.001), along with a decreased platelet level compared to the control group [(202.55±73.67) vs. (256.63±72.85) ×109/L]. Furthermore, echocardiographic indicators related to right heart function showed correlations with red blood cell count, bilirubin, albumin, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol (multiple significant correlation coefficient r, magnitude from 0.22 to 0.54).

Conclusions: Chronic pulmonary disease and left heart disease were identified as common etiologies of PH among Tibetan patients residing in high-altitude regions. The Tibetan population residing in high-altitude regions and diagnosed with PH displayed abnormal changes in numerous liver functional and metabolic indices, which were correlated with the morphological indices observed via cardiac ultrasound.

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来源期刊
Cardiovascular diagnosis and therapy
Cardiovascular diagnosis and therapy Medicine-Cardiology and Cardiovascular Medicine
CiteScore
4.90
自引率
4.20%
发文量
45
期刊介绍: The journal ''Cardiovascular Diagnosis and Therapy'' (Print ISSN: 2223-3652; Online ISSN: 2223-3660) accepts basic and clinical science submissions related to Cardiovascular Medicine and Surgery. The mission of the journal is the rapid exchange of scientific information between clinicians and scientists worldwide. To reach this goal, the journal will focus on novel media, using a web-based, digital format in addition to traditional print-version. This includes on-line submission, review, publication, and distribution. The digital format will also allow submission of extensive supporting visual material, both images and video. The website www.thecdt.org will serve as the central hub and also allow posting of comments and on-line discussion. The web-site of the journal will be linked to a number of international web-sites (e.g. www.dxy.cn), which will significantly expand the distribution of its contents.
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