通过血管矢量流图评估健康成年人颈动脉中与年龄相关的壁剪应力变化:一项横断面研究。

IF 2.1 3区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Cardiovascular diagnosis and therapy Pub Date : 2024-08-31 Epub Date: 2024-08-16 DOI:10.21037/cdt-24-134
Lan He, Yundan Cai, Yuhong Feng, Tienan Feng, Filippo Cademartiri, E Shen
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引用次数: 0

摘要

背景:壁剪应力(WSS)与动脉粥样硬化的发病机制有关。WSS 受多种血流动力学因素的影响,目前仍缺乏准确、客观的测量方法。本研究试图利用血管矢量血流图(VFM)评估不同年龄健康成人颈总动脉WSS最大值(max)、WSS平均值(mean)和WSS最小值(min)的血流动力学变化:我们对 2021 年 2 月至 2021 年 6 月期间从超声科招募的 70 名年龄在 20-89 岁之间的健康志愿者进行了回顾性分析。使用带有 3-15 MHz 探头的超声系统确定颈总动脉的感兴趣区(ROI)。通过从三个完整的心动周期中选择图像质量最佳的 ROI,获得基于 VFM 的 WSS 测量值。参与者被分为以下七个年龄组:20 岁组、30 岁组、40 岁组、50 岁组、60 岁组、70 岁组和 80 岁组。对各年龄组的 WSS 参数进行比较。采用方差分析或 Kruskal-Wallis 检验评估各组之间的差异,并采用皮尔逊分析和线性回归进行相关性和趋势分析:使用血管VFM软件对WSS参数进行量化。各年龄组的 WSSmax、WSSmean、WSSmin 存在差异,且随年龄增长逐渐降低,老年人明显低于年轻人。WSSmax与年龄的皮尔逊相关系数为-0.556(Pmean与年龄的皮尔逊相关系数为-0.461(Pmin与年龄的皮尔逊相关系数为-0.308(PConclusions)):使用血管VFM技术可对颈动脉WSSmax、WSSmean和WSSmin进行定量和直观分析。在不同年龄的健康成年人中,颈动脉 WSSmax、WSSmean 和 WSSmin 随年龄的增长而下降。我们对颈动脉WSS正常值的研究结果或许对今后的研究具有临床参考价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Age-related wall shear stress changes assessed by vascular vector flow mapping in the carotid arteries of healthy adults: a cross-sectional study.

Background: Wall shear stress (WSS) is related to the pathogenesis of atherosclerosis. WSS is affected by a variety of hemodynamic factors, and there is still a lack of accurate and objective methods for measuring it. This study sought to evaluate hemodynamic changes in WSSmaximum (max), WSSmean, WSSminimum (min) in the common carotid artery of healthy adults of different ages using vascular vector flow mapping (VFM).

Methods: A retrospective analysis was conducted on 70 healthy volunteers aged 20-89 years who were recruited from our Ultrasound Department between February 2021 and June 2021. An ultrasound system with a 3-15 MHz probe was used to determine regions of interest (ROIs) of the common carotid artery. VFM-based WSS measurements were obtained by selecting ROIs with optimal image quality from three full cardiac cycles. The participants were divided into the following seven age groups: the 20s group, the 30s group, the 40s group, the 50s group, the 60s group, the 70s group, and the 80s group. The WSS parameters were compared among the age groups. An analysis of variance or a Kruskal-Wallis test was used to evaluate the difference among the groups, and a Pearson analysis and linear regression were used for the correlation and trend analysis.

Results: The WSS parameters were quantified using vascular VFM software. The WSSmax, WSSmean, WSSmin differed among the age groups and gradually decreased with age, the elderly were significantly lower than the young. The Pearson correlation coefficient of the WSSmax and age was -0.556 (P<0.001), that of the WSSmean and age was -0.461 (P<0.001), and that of the WSSmin and age was -0.308 (P<0.001). The WSS parameters with age are negatively correlated the carotid intima-media thickness differed between the groups.

Conclusions: The carotid WSSmax, WSSmean, WSSmin can be quantitatively and visually analyzed using the vascular VFM technique. In healthy adults of different ages, the carotid WSSmax, WSSmean, WSSmin decreased with age. Our findings about the normal values of carotid WSS maybe have clinical reference value for future studies.

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来源期刊
Cardiovascular diagnosis and therapy
Cardiovascular diagnosis and therapy Medicine-Cardiology and Cardiovascular Medicine
CiteScore
4.90
自引率
4.20%
发文量
45
期刊介绍: The journal ''Cardiovascular Diagnosis and Therapy'' (Print ISSN: 2223-3652; Online ISSN: 2223-3660) accepts basic and clinical science submissions related to Cardiovascular Medicine and Surgery. The mission of the journal is the rapid exchange of scientific information between clinicians and scientists worldwide. To reach this goal, the journal will focus on novel media, using a web-based, digital format in addition to traditional print-version. This includes on-line submission, review, publication, and distribution. The digital format will also allow submission of extensive supporting visual material, both images and video. The website www.thecdt.org will serve as the central hub and also allow posting of comments and on-line discussion. The web-site of the journal will be linked to a number of international web-sites (e.g. www.dxy.cn), which will significantly expand the distribution of its contents.
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