Mandukparni (Centella asiatica Linn Urban) 在神经系统疾病中的作用：从民族药理学和临床研究到网络富集分析的证据。

IF 4.4 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Neurochemistry international Pub Date : 2024-09-20 DOI:10.1016/j.neuint.2024.105865

Ruchi Sharma , Subhadip Banerjee , Rohit Sharma

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引用次数: 0

摘要

积雪草（Centella asiatica Linn Urban），又名曼杜克帕尼（Mandukparni），是传统医学中用于有效治疗神经问题的主要草药之一。虽然这种植物拥有丰富全面的临床前药理特征，但仍需要进一步的临床研究并确定其分子作用模式。我们使用相关关键词搜索了电子数据库（Google Scholar、SciFinder、MEDLINE、Scopus、EMBASE、Science Direct 和 PubMed），检索了截至 2023 年 6 月有关茜草的信息，并进行了网络药理学研究，以了解其神经生物学作用的相关机制。本研究广泛分析了其药理特性、营养成分、民族医药用途、安全性以及在治疗神经和神经退行性疾病中的作用机制。此外，还进行了一项网络药理学研究，表明其植物大分子参与了不同的神经活性配体-受体通路、神经胶质细胞分化、神经胶质细胞生成和星形胶质细胞分化。希望本报告能促使医学实践、研究和针对中枢神经系统的茜草提取物植物药的开发发生范式转变。

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Role of Mandukparni (Centella asiatica Linn Urban) in neurological disorders: Evidence from ethnopharmacology and clinical studies to network enrichment analysis

Centella asiatica Linn Urban (C. asiatica), aka Mandukparni, is one of the flagship herbs used in traditional medicines to effectively manage neurological problems. Although this plant has a wealth of comprehensive preclinical pharmacological profiles, further clinical research and execution of its molecular mode of action are still required. We searched electronic databases (Google Scholar, SciFinder, MEDLINE, Scopus, EMBASE, Science Direct, and PubMed) using relevant key words to retrieve information pertaining to C. asiatica till June 2023 and performed network pharmacology to understand the mechanism related to their neurobiological roles. This study extensively analyses its pharmacological properties, nutritional profile, ethnomedical uses, safety, and mechanistic role in treating neurological and neurodegenerative disorders. Additionally, a network pharmacology study was performed which suggests that its phytomolecules are involved in different neuroactive ligand-receptor pathways, glial cell differentiation, gliogenesis, and astrocyte differentiation. Hopefully, this report will lead to a paradigm shift in medical practice, research, and the creation of phytopharmaceuticals derived from C. asiatica that target the central nervous system.

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来源期刊

Neurochemistry international 医学-神经科学

CiteScore

8.40

自引率

2.40%

发文量

128

审稿时长

37 days

期刊介绍： Neurochemistry International is devoted to the rapid publication of outstanding original articles and timely reviews in neurochemistry. Manuscripts on a broad range of topics will be considered, including molecular and cellular neurochemistry, neuropharmacology and genetic aspects of CNS function, neuroimmunology, metabolism as well as the neurochemistry of neurological and psychiatric disorders of the CNS.