2 型糖尿病患者的体重调整后腰围指数与全因死亡率和心血管死亡率之间的关系。

IF 5.4 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes, Obesity & Metabolism Pub Date : 2024-09-18 DOI:10.1111/dom.15929

Tian-Yu Zhang, Zi-Meng Zhang, Xue-Ning Wang, Hong-Yu Kuang, Qian Xu, Hong-Xue Li, Cheng-Ye Xu, Kang-Qi Zhao, Cong Zhang, Ming Hao

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引用次数: 0

摘要

目的：研究2型糖尿病患者的体重调整腰围指数（WWI）与全因死亡率以及心血管死亡率之间的关系：我们使用的数据来自 1999 年至 2018 年的美国国家健康与营养调查（NHANES）和英国生物库数据库。采用限制性三次样条曲线和Cox比例危险模型评估全因死亡率的危险比（HRs）和95%置信区间（CIs）：在英国生物库数据库中，与一战最低四分位数相比，在完全调整模型中，最高四分位数的全因死亡和心血管死亡的危险比分别为 1.846（95% CI 1.687-2.019）和 2.118（95% CI 1.783-2.517）。在NHANES数据库中，与WWI最低四分位数相比，在完全调整模型中，最高四分位数的全因死亡HR为1.727（95% CI 1.378-2.163），心血管死亡HR为1.719（95% CI 1.139-2.595）：我们的研究表明，WWI 对 2 型糖尿病患者的全因死亡率和心血管死亡率具有长期协同负面影响。WWI是预测2型糖尿病患者死亡率的一个独立指标。

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Relationship between weight-adjusted-waist index and all-cause and cardiovascular mortality in individuals with type 2 diabetes.

Aim: To investigate the relationship between the weight-adjusted-waist index (WWI) and all-cause mortality as well as cardiovascular mortality in individuals with type 2 diabetes.

Methods: We used data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018 and the UK Biobank database. Restricted cubic spline curves and Cox proportional hazards models were employed to assess hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause mortality.

Results: In the UK Biobank database, compared with the lowest WWI quartile, the HR for all-cause and cardiovascular death in the highest quartile was 1.846 (95% CI 1.687-2.019) and 2.118 (95% CI 1.783-2.517), respectively, in the fully adjusted model. In the NHANES database, compared with the lowest WWI quartile, the highest quartile had an HR of 1.727 (95% CI 1.378-2.163) for all-cause death and 1.719 (95% CI 1.139-2.595) for cardiovascular death in the fully adjusted model.

Conclusions: Our study indicates that WWI has a long-term synergistic negative impact on all-cause mortality and cardiovascular mortality in individuals with type 2 diabetes. The WWI is an independent predictor of mortality in individuals with type 2 diabetes.

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来源期刊

Diabetes, Obesity & Metabolism 医学-内分泌学与代谢

CiteScore

10.90

自引率

6.90%

发文量

319

审稿时长

3-8 weeks

期刊介绍： Diabetes, Obesity and Metabolism is primarily a journal of clinical and experimental pharmacology and therapeutics covering the interrelated areas of diabetes, obesity and metabolism. The journal prioritises high-quality original research that reports on the effects of new or existing therapies, including dietary, exercise and lifestyle (non-pharmacological) interventions, in any aspect of metabolic and endocrine disease, either in humans or animal and cellular systems. ‘Metabolism’ may relate to lipids, bone and drug metabolism, or broader aspects of endocrine dysfunction. Preclinical pharmacology, pharmacokinetic studies, meta-analyses and those addressing drug safety and tolerability are also highly suitable for publication in this journal. Original research may be published as a main paper or as a research letter.