20(S)-人参皂苷Rh2通过抑制LAMC2调节的ABC转运体克服胰腺癌患者对吉西他滨的耐药性

IF 11.4 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Journal of Advanced Research Pub Date : 2024-09-11 DOI:10.1016/j.jare.2024.09.006

Yulin Wu, Juan Zhang, Yuanyang Tian, William Chi Shing Cho, Hong-Xi Xu, Zhi-Xiu Lin, Yan-Fang Xian

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引用次数: 0

摘要

吉西他滨（GEM）是治疗胰腺导管腺癌（PDAC）的一线药物，但耐药性严重制约了其化疗效果。层粘连蛋白亚基γ2（LAMC2）在细胞外基质的形成过程中起着至关重要的作用，导致了GEM耐药性的产生。然而，LAMC2 在 GEM 抗性中的生物学功能及其分子机制仍不清楚。20(S)-Ginsenoside Rh2（Rh2）是从人参中分离出来的主要活性成分之一，具有很强的抗肿瘤作用。然而，Rh2 对克服 GEM 抗药性的作用及其作用机制仍有待阐明。

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20(S)-Ginsenoside Rh2 overcomes gemcitabine resistance in pancreatic cancer by inhibiting LAMC2-Modulated ABC transporters

Gemcitabine (GEM) is the first-line drug for pancreatic ductal adenocarcinoma (PDAC), but drug resistance severely restricts its chemotherapeutic efficacy. Laminin subunit γ2 (LAMC2) plays a crucial role in extracellular matrix formation in the development of GEM-resistance. However, the biological function of LAMC2 in GEM resistance and its molecular mechanisms are still unclear. 20(S)-Ginsenoside Rh2 (Rh2), one of the principal active components isolated from Ginseng Radix et Rhizoma, possesses strong anti-tumor effects. However, the effects of Rh2 on overcoming GEM resistance and its action mechanisms remain to be elucidated.

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来源期刊

Journal of Advanced Research Multidisciplinary-Multidisciplinary

CiteScore

21.60

自引率

0.90%

发文量

280

审稿时长

12 weeks

期刊介绍： Journal of Advanced Research (J. Adv. Res.) is an applied/natural sciences, peer-reviewed journal that focuses on interdisciplinary research. The journal aims to contribute to applied research and knowledge worldwide through the publication of original and high-quality research articles in the fields of Medicine, Pharmaceutical Sciences, Dentistry, Physical Therapy, Veterinary Medicine, and Basic and Biological Sciences. The following abstracting and indexing services cover the Journal of Advanced Research: PubMed/Medline, Essential Science Indicators, Web of Science, Scopus, PubMed Central, PubMed, Science Citation Index Expanded, Directory of Open Access Journals (DOAJ), and INSPEC.