西司他丁：治疗急性肾损伤的新希望

IF 14.8 1区医学 Q1 UROLOGY & NEPHROLOGY

Kidney international Pub Date : 2024-09-18 DOI:10.1016/j.kint.2024.07.024

María Ángeles González-Nicolás , Alberto Lázaro

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引用次数: 0

摘要

急性肾损伤是一种由多种原因引起的破坏性临床综合征，其特点是肾功能突然恶化，目前尚无药物治疗方法。西司他丁对急性肾损伤有直接的肾保护作用，现在已证明它能有效地将具有治疗作用的纳米颗粒特异性地靶向到近端肾小管，以治疗急性肾损伤。

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Cilastatin, a new therapeutic promise for acute kidney injury

Acute kidney injury is a devasting clinical syndrome resulting from multiple causes, characterized by an abrupt deterioration of kidney function for which there is no pharmacologic treatment. Cilastatin has demonstrated direct nephroprotective effects in acute kidney injury and now is shown to be effective to specifically target therapeutically loaded nanoparticles to the proximal tubule to treat acute kidney injury.

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来源期刊

Kidney international 医学-泌尿学与肾脏学

CiteScore

23.30

自引率

3.10%

发文量

490

审稿时长

3-6 weeks

期刊介绍： Kidney International (KI), the official journal of the International Society of Nephrology, is led by Dr. Pierre Ronco (Paris, France) and stands as one of nephrology's most cited and esteemed publications worldwide. KI provides exceptional benefits for both readers and authors, featuring highly cited original articles, focused reviews, cutting-edge imaging techniques, and lively discussions on controversial topics. The journal is dedicated to kidney research, serving researchers, clinical investigators, and practicing nephrologists.