较新的线粒体动力学及其在肝脏再生中的钙信号作用

IF 3.9 3区生物学 Q2 CELL BIOLOGY

Mitochondrion Pub Date : 2024-09-19 DOI:10.1016/j.mito.2024.101969

Onkar Bedi , Vaibhav Sapra , Manish Kumar , Pawan Krishan

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引用次数: 0

摘要

肝脏再生是细胞增殖、分化和组织修复的关键过程。钙信号对肝细胞生长因子-甲胎蛋白-酪氨酸激酶（HGF-Met）转导途径、表皮生长因子受体（EGFR）信号和钙介导的核 SKHep1 细胞增殖途径等关键途径产生影响。肝细胞内的钙储存被认为是诱导钙介导的再生过程的基础。钙信号与 HGF、TGF-β 和 NF-κB 信号相互作用，影响干细胞行为并触发 MAPK 级联。线粒体钙通过调节细胞凋亡和细胞分裂影响肝脏再生。总之，钙信号有望用于肝脏干预治疗。

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Newer mitochondrial dynamics and their role of calcium signalling in liver regeneration

Liver regeneration is a crucial process involved in cellular proliferation, differentiation, and tissue repair. Calcium signaling impact key pathways like hepatocyte growth factor-Met-tyrosine kinase (HGF-Met) transduction pathway, the epidermal growth factor receptor (EGFR) signaling and Ca-mediated nuclear SKHep1 cell proliferation pathway. Intracellular hepatocyte calcium stores are considered as base for the induction of ca-mediated regeneration process. Calcium signaling interplays with HGF, TGF-β, and NF-κB signaling, influence stem cell behavior and triggers MAPK cascade. The mitochondria calcium is impacting on liver rejuvenation by regulating apoptosis and cell division. In conclusion, it is stated that calcium-signaling holds promise for therapeutic liver interventions.

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来源期刊

Mitochondrion 生物-细胞生物学

CiteScore

9.40

自引率

4.50%

发文量

审稿时长

13.6 weeks

期刊介绍： Mitochondrion is a definitive, high profile, peer-reviewed international research journal. The scope of Mitochondrion is broad, reporting on basic science of mitochondria from all organisms and from basic research to pathology and clinical aspects of mitochondrial diseases. The journal welcomes original contributions from investigators working in diverse sub-disciplines such as evolution, biophysics, biochemistry, molecular and cell biology, genetics, pharmacology, toxicology, forensic science, programmed cell death, aging, cancer and clinical features of mitochondrial diseases.