局部 TSH/TSHR 信号促进结直肠癌 CD8+ T 细胞衰竭和免疫逃避

IF 20.1 1区医学 Q1 ONCOLOGY

Cancer Communications Pub Date : 2024-09-16 DOI:10.1002/cac2.12605

Sisi Zeng, Huiling Hu, Zhiyang Li, Qi Hu, Rong Shen, Mingzhou Li, Yunshi Liang, Zuokang Mao, Yandong Zhang, Wanqi Zhan, Qin Zhu, Feifei Wang, Jianbiao Xiao, Bohan Xu, Guanglong Liu, Yanan Wang, Bingsong Li, Shaowan Xu, Zhaowen Zhang, Ceng Zhang, Zhizhang Wang, Li Liang

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引用次数: 0

摘要

肿瘤微环境（TME）中的 CD8+ T 细胞功能失调会导致肿瘤免疫逃逸和免疫治疗耐受。瘦素、类固醇激素和糖皮质激素等激素对T细胞功能的影响已有报道。然而，促甲状腺激素（TSH）/促甲状腺激素受体（TSHR）信号在CD8+ T细胞衰竭和肿瘤免疫逃避中的作用机制仍不甚明了。本研究旨在探讨TSH/TSHR信号对CD8+ T细胞功能和结直肠癌（CRC）免疫逃避的影响。

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Local TSH/TSHR signaling promotes CD8+ T cell exhaustion and immune evasion in colorectal carcinoma

Dysfunction of CD8⁺ T cells in the tumor microenvironment (TME) contributes to tumor immune escape and immunotherapy tolerance. The effects of hormones such as leptin, steroid hormones, and glucocorticoids on T cell function have been reported previously. However, the mechanism underlying thyroid-stimulating hormone (TSH)/thyroid-stimulating hormone receptor (TSHR) signaling in CD8⁺ T cell exhaustion and tumor immune evasion remain poorly understood. This study was aimed at investigating the effects of TSH/TSHR signaling on the function of CD8⁺ T cells and immune evasion in colorectal cancer (CRC).

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来源期刊

Cancer Communications Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

25.50

自引率

4.30%

发文量

153

审稿时长

4 weeks

期刊介绍： Cancer Communications is an open access, peer-reviewed online journal that encompasses basic, clinical, and translational cancer research. The journal welcomes submissions concerning clinical trials, epidemiology, molecular and cellular biology, and genetics.