{"title":"夫西地酸乙炔基和 1,2,3-三唑基类似物的合成","authors":"E. V. Salimova, L. V. Parfenova","doi":"10.1007/s11172-024-4354-z","DOIUrl":null,"url":null,"abstract":"<p>In continuation of our studies on modification of fusidane triterpenoids, the alkynyl moieties were introduced into fusidic acid to synthesize new compounds promising as antimicrobial and antitumor agents. Transformations of the triple bond <i>via</i> the Cu<sup>I</sup>-catalyzed reactions afforded new 1,2,3-triazoles as well as mono- and diacetylenic derivatives.</p>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis of acetylenic and 1,2,3-triazolyl analogs of fusidic acid\",\"authors\":\"E. V. Salimova, L. V. Parfenova\",\"doi\":\"10.1007/s11172-024-4354-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>In continuation of our studies on modification of fusidane triterpenoids, the alkynyl moieties were introduced into fusidic acid to synthesize new compounds promising as antimicrobial and antitumor agents. Transformations of the triple bond <i>via</i> the Cu<sup>I</sup>-catalyzed reactions afforded new 1,2,3-triazoles as well as mono- and diacetylenic derivatives.</p>\",\"PeriodicalId\":756,\"journal\":{\"name\":\"Russian Chemical Bulletin\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2024-09-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Russian Chemical Bulletin\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1007/s11172-024-4354-z\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Chemical Bulletin","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1007/s11172-024-4354-z","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
摘要
在继续研究改性夫西地三萜类化合物的过程中,我们将炔基引入夫西地酸,合成了有望用作抗菌剂和抗肿瘤剂的新化合物。通过 CuI 催化的三键转化反应,获得了新的 1,2,3-三唑以及单乙酰基和双乙酰基衍生物。
Synthesis of acetylenic and 1,2,3-triazolyl analogs of fusidic acid
In continuation of our studies on modification of fusidane triterpenoids, the alkynyl moieties were introduced into fusidic acid to synthesize new compounds promising as antimicrobial and antitumor agents. Transformations of the triple bond via the CuI-catalyzed reactions afforded new 1,2,3-triazoles as well as mono- and diacetylenic derivatives.
期刊介绍:
Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections:
General and Inorganic Chemistry;
Physical Chemistry;
Organic Chemistry;
Organometallic Chemistry;
Chemistry of Natural Compounds and Bioorganic Chemistry.