琥珀酸官能化有机磷衍生物的合成

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2024-09-19 DOI:10.1007/s11172-024-4358-8

Yu. N. Bubnov, A. A. Prishchenko, M. V. Livantsov, O. P. Novikova, L. I. Livantsova, S. V. Baranin

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引用次数: 0

摘要

我们开发出了琥珀酸含磷衍生物的便捷合成方法，这些衍生物含有官能化的膦酸、膦酸和膦酸分子。双（三甲基硅氧基）膦与马来酸、衣康酸和乙酰二羧酸的二酯进行亲核加成反应时，可进行区域选择性反应，生成多种官能化膦酸盐。这些化合物进一步氨甲基化后可得到各种目标酸衍生物。由此产生的化合物是很有前景的生物活性物质和水溶性配体。

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Synthesis of functionalized organophosphorus derivatives of succinic acid

Convenient synthesis of phosphorus-containing derivatives of succinic acid, which contain functionalized phosphonous, phosphonic, and phosphinic acid moieties have been developed. The nucleophilic addition of bis(trimethylsiloxy)phosphine to diesters of maleic, itaconic, and acetylenedicarboxylic acids proceeds regioselectively to give a number of functionalized phosphonites. Further aminomethylation of these compounds affords various target acid derivatives. The resulting compounds are of interest as promising biologically active substances and water-soluble ligands.

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.