对携带生殖系 BRCA 或其他 DNA 损伤修复系统变异的预处理转移性胰腺癌患者进行氯霉素试点研究

IF 2.8 2区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Pancreatology Pub Date : 2024-09-12 DOI:10.1016/j.pan.2024.09.006

Catia Carconi, Carlo Bosi, Mario Scartozzi, Massimiliano Cergnul, Marika Cinausero, Luca Faloppi, Ingrid Garajova, Sara Lonardi, Irene Pecora, Laura Pisanu, Rosella Spadi, Andrea Spallanzani, Umberto Peretti, Marina Macchini, Giulia Orsi, Michele Reni

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引用次数: 0

摘要

胰腺腺癌仍然是一种预后严重、个性化治疗方案匮乏的恶性肿瘤。DNA损伤修复（DDR）基因的致病变异正在成为分子靶点，因为它们对DNA损伤药物具有更高的敏感性。本研究旨在评估氯霉素作为挽救疗法对带有DDR相关基因种系致病变异或意义不确定变异的转移性胰腺癌患者的活性。

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A pilot study of chlorambucil in pre-treated metastatic pancreatic adenocarcinoma patients bearing germline BRCA or other DNA damage repair system variants

Pancreatic adenocarcinoma remains a malignancy with a grim prognosis and scarce personalized treatment options. Pathogenic variants of DNA damage repair (DDR) genes are emerging as molecular targets, as they confer a higher sensitivity to DNA-damaging agents. This study aimed at assessing the activity of chlorambucil as salvage therapy in metastatic pancreatic cancer patients bearing a germline pathogenetic variant or variant of uncertain significance on a DDR-related gene.

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来源期刊

Pancreatology 医学-胃肠肝病学

CiteScore

7.20

自引率

5.60%

发文量

194

审稿时长

44 days

期刊介绍： Pancreatology is the official journal of the International Association of Pancreatology (IAP), the European Pancreatic Club (EPC) and several national societies and study groups around the world. Dedicated to the understanding and treatment of exocrine as well as endocrine pancreatic disease, this multidisciplinary periodical publishes original basic, translational and clinical pancreatic research from a range of fields including gastroenterology, oncology, surgery, pharmacology, cellular and molecular biology as well as endocrinology, immunology and epidemiology. Readers can expect to gain new insights into pancreatic physiology and into the pathogenesis, diagnosis, therapeutic approaches and prognosis of pancreatic diseases. The journal features original articles, case reports, consensus guidelines and topical, cutting edge reviews, thus representing a source of valuable, novel information for clinical and basic researchers alike.