将免疫中的分泌和细胞骨架联系起来--拟南芥 TGNap1 的一个案例

IF 3.2 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

BioEssays Pub Date : 2024-09-20 DOI:10.1002/bies.202400150

Deepak D. Bhandari, Federica Brandizzi

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引用次数: 0

摘要

在植物中，强大的防御能力取决于将供应链高效、灵活地运送到病原体攻击地点。虽然细胞内运输在植物免疫中的重要性已得到充分证实，但各种运输途径在运输免疫相关蛋白方面的贡献仍不明确。我们最近发现了一种跨高尔基体网络蛋白--TGN-ASSOCIATED PROTEIN 1（TGNap1），它在功能上将高尔基体后囊泡与细胞骨架连接起来，从而在模式植物拟南芥中运输免疫相关蛋白。我们就 TGNap1 的各种功能意义提出了新的假设，然后阐述了近年来发现的 TGNap1 和其他 TGN 相关蛋白所揭示的免疫过程中 TGN 囊泡的惊人异质性。

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Linking secretion and cytoskeleton in immunity– a case for Arabidopsis TGNap1

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Linking secretion and cytoskeleton in immunity– a case for Arabidopsis TGNap1

In plants, robust defense depends on the efficient and resilient trafficking supply chains to the site of pathogen attack. Though the importance of intracellular trafficking in plant immunity has been well established, a lack of clarity remains regarding the contribution of the various trafficking pathways in transporting immune-related proteins. We have recently identified a trans-Golgi network protein, TGN-ASSOCIATED PROTEIN 1 (TGNap1), which functionally links post-Golgi vesicles with the cytoskeleton to transport immunity-related proteins in the model plant species Arabidopsis thaliana. We propose new hypotheses on the various functional implications of TGNap1 and then elaborate on the surprising heterogeneity of TGN vesicles during immunity revealed by the discovery of TGNap1 and other TGN-associated proteins in recent years.

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来源期刊

BioEssays 生物-生化与分子生物学

CiteScore

7.30

自引率

2.50%

发文量

167

审稿时长

4-8 weeks

期刊介绍： molecular – cellular – biomedical – physiology – translational research – systems - hypotheses encouraged BioEssays is a peer-reviewed, review-and-discussion journal. Our aims are to publish novel insights, forward-looking reviews and commentaries in contemporary biology with a molecular, genetic, cellular, or physiological dimension, and serve as a discussion forum for new ideas in these areas. An additional goal is to encourage transdisciplinarity and integrative biology in the context of organismal studies, systems approaches, through to ecosystems, where appropriate.