非疟疾流行国家的输入性疟疾:西班牙马德里南部一家医院十六年来的病例

IF 3.7 3区 医学 Q2 INFECTIOUS DISEASES
Víctor Antón-Berenguer, Irene Cabrera-Rodrigo, Beatriz Valle-Borrego, Jorge Ligero-López, Francisco J. Merino-Fernández, Sara Gómez-de-Frutos, José Miguel Rubio
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引用次数: 0

摘要

目的 疟疾一直是全球健康的严重威胁,尤其是在疟疾流行的许多热带国家。方法 这是一项回顾性研究,包括 2006 年至 2022 年期间在塞韦罗-奥乔亚大学医院确诊的所有疟疾患者,并根据以下因素进行分类:(结果在这项研究中,132 名患者(占所有疑似病例的 23.7%)被确诊为疟疾患者。聚合酶链式反应是最灵敏的技术(99.2%),其次是抗原检测(78.8%)和显微镜检查(75%),恶性疟原虫是主要的疟原虫种类(94.7%)。VFR 是感染疟疾的最大群体(69.7%),大多无症状(98.2%),表现为 MM(90.2%)。相反,MRA 患者(25%)症状较轻(47.4%)或无症状(31.6%),SMM 病例较多(42.4%)。有 19 名患者(14.4%)合并感染了另一种输入病原体,其中 MRA 患者合并感染的比例更高(30.3%)。就 MRA 而言,应在他们抵达后对输入性疾病进行筛查。最后,我们重点介绍了两例合并感染输入病毒的病例,这表明,出现与另一种输入病原体引起的疟疾相似的症状并不能排除疟疾的可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Imported malaria in a non-endemic country: sixteen years of cases in a hospital in the South of Madrid, Spain

Imported malaria in a non-endemic country: sixteen years of cases in a hospital in the South of Madrid, Spain

Purpose

Malaria keeps on being a serious global health threat, especially in many tropical countries, where it is endemic. Also in non-endemic countries, like Spain, malaria is an issue that requires attention due to the presence of imported cases.

Methods

This is a retrospective study, including all patients diagnosed with malaria at Severo Ochoa University Hospital from 2006 to 2022, being classified according to: (I) their type of stay in an endemic area as visiting friends and relatives (VFR), migrants of recent arrival (MRA), or tourism and business (T&B), and (II) the mode of presentation as microscopic (MM) or submicroscopic (SMM) malaria.

Results

In this study, 132 patients (23.7% of all suspected) were diagnosed with malaria. The PCR was the most sensitive technique (99.2%), followed by antigen detection (78.8%) and microscopy (75%), with Plasmodium falciparum being the predominant species (94.7%). VFR was the largest group infected with malaria (69.7%), mostly symptomatic (98.2%) and presenting MM (90.2%). Instead, MRA patients (25%) presented milder (47.4%) or no symptoms (31.6%) and higher cases of SMM (42.4%). Coinfection with another imported pathogen was present in 19 patients (14.4%), being MRA more frequently coinfected (30.3%)

Conclusion

This study shows the need for establishing systems for VFRs to attend pre-travel consultations to reduce malaria imported risk. In the case of MRA, screening for imported diseases should be conducted upon their arrival. Finally, we highlight two cases of co-infection with imported viruses, showing that presence of symptoms resembling malaria from another imported pathogen does not exclude malaria.

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来源期刊
CiteScore
10.40
自引率
2.20%
发文量
138
审稿时长
1 months
期刊介绍: EJCMID is an interdisciplinary journal devoted to the publication of communications on infectious diseases of bacterial, viral and parasitic origin.
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