含碳青霉烯酶的肺炎克雷伯菌：南非社区医院中含 blaOXA181 的序列 307 型的高流行率

IF 3.7 3区医学 Q2 INFECTIOUS DISEASES

European Journal of Clinical Microbiology & Infectious Diseases Pub Date : 2024-09-17 DOI:10.1007/s10096-024-04947-z

Kafilat Taiwo Salvador-Oke, Johann D. D. Pitout, Gisele Peirano, Kathy-Anne Strydom, Chanel Kingsburgh, Marthie M. Ehlers, Marleen M. Kock

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引用次数: 0

摘要

本研究采用简单、经济有效的 PCR 方法，调查了南非豪登省尿液中产碳青霉烯酶肺炎克雷伯氏菌分离物（n = 194）的分子特征。在豪登省的社区医院中，带有 blaOXA-181 的 IncX3 质粒的 ST307 具有广泛耐药性 (XDR)，因此治疗门诊和住院患者尿路感染的选择非常有限。在携带 blaOXA-48-like（包括 blaOXA-181）的分离株中检测到了高水平的头孢他啶/阿维菌素耐药性。这些发现突出表明，社区医院需要适合中低收入国家的基因组方法来追踪 XDR 克隆和质粒。这些结果将有助于制定治疗和管理策略。

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Klebsiella pneumoniae with carbapenemases: high prevalence of sequence type 307 with blaOXA181 in South African community hospitals

This study investigated the molecular characteristics of urinary carbapenemase-producing Klebsiella pneumoniae isolates (n = 194) in Gauteng, South Africa, using simple, cost-effective PCR methodologies. Extensively drug resistant (XDR) ST307 with bla_OXA-181 on IncX3 plasmids was endemic in Gauteng community hospitals leaving limited options for treating in- and outpatient urinary tract infections. High-level ceftazidime/avibactam resistance was detected among isolates harbouring bla_OXA-48-like including bla_OXA-181. These findings highlighted the need for genomic methodologies suitable for lower- and middle-income countries to track XDR clones and plasmids in community hospitals. Such results will aid with treatment and stewardship strategies.

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来源期刊

European Journal of Clinical Microbiology & Infectious Diseases 医学-传染病学

CiteScore

10.40

自引率

2.20%

发文量

138

审稿时长

1 months

期刊介绍： EJCMID is an interdisciplinary journal devoted to the publication of communications on infectious diseases of bacterial, viral and parasitic origin.