为什么流动遗传因子会转移宿主的 DNA？

IF 13.6 2区生物学 Q1 GENETICS & HEREDITY

Trends in Genetics Pub Date : 2024-09-19 DOI:10.1016/j.tig.2024.07.008

Michiel Vos, Angus Buckling, Bram Kuijper, Adam Eyre-Walker, Cyril Bontemps, Pierre Leblond, Tatiana Dimitriu

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引用次数: 0

摘要

原核生物界充满了移动遗传因子（MGEs）--可以在宿主体内和宿主之间移动的自我复制实体。许多移动遗传因子不仅会将自身的 DNA 转移到新的宿主身上，还会在此过程中将宿主染色体上其他位置的 DNA 转移到新的宿主身上。当染色体变异的增加导致更有效的自然选择时，这可能会给宿主带来间接的好处。我们回顾了MGEs促进宿主DNA转移的各种方式，并探讨了MGEs和宿主的收益和成本。在许多情况下，MGE介导的宿主DNA转移可能不会因为性功能而被选择，但MGE驯化的证据表明，MGE介导的性可能会给宿主带来益处。

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Why do mobile genetic elements transfer DNA of their hosts?

The prokaryote world is replete with mobile genetic elements (MGEs) – self-replicating entities that can move within and between their hosts. Many MGEs not only transfer their own DNA to new hosts but also transfer host DNA located elsewhere on the chromosome in the process. This could potentially lead to indirect benefits to the host when the resulting increase in chromosomal variation results in more efficient natural selection. We review the diverse ways in which MGEs promote the transfer of host DNA and explore the benefits and costs to MGEs and hosts. In many cases, MGE-mediated transfer of host DNA might not be selected for because of a sex function, but evidence of MGE domestication suggests that there may be host benefits of MGE-mediated sex.

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来源期刊

Trends in Genetics 生物-遗传学

CiteScore

20.90

自引率

0.90%

发文量

160

审稿时长

6-12 weeks

期刊介绍： Launched in 1985, Trends in Genetics swiftly established itself as a "must-read" for geneticists, offering concise, accessible articles covering a spectrum of topics from developmental biology to evolution. This reputation endures, making TiG a cherished resource in the genetic research community. While evolving with the field, the journal now embraces new areas like genomics, epigenetics, and computational genetics, alongside its continued coverage of traditional subjects such as transcriptional regulation, population genetics, and chromosome biology. Despite expanding its scope, the core objective of TiG remains steadfast: to furnish researchers and students with high-quality, innovative reviews, commentaries, and discussions, fostering an appreciation for advances in genetic research. Each issue of TiG presents lively and up-to-date Reviews and Opinions, alongside shorter articles like Science & Society and Spotlight pieces. Invited from leading researchers, Reviews objectively chronicle recent developments, Opinions provide a forum for debate and hypothesis, and shorter articles explore the intersection of genetics with science and policy, as well as emerging ideas in the field. All articles undergo rigorous peer-review.