OGT 在癌症中的作用及其机制

IF 6.1 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell and Bioscience Pub Date : 2024-09-16 DOI:10.1186/s13578-024-01301-w

Xin Liu, Jing Wang, Yaoxian Xiang, Kangjie Wang, Dong Yan, Yingying Tong

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引用次数: 0

摘要

O-连锁-N-乙酰葡萄糖氨酰化（O-GlcNAcylation）是一种常见而重要的翻译后修饰（PTM），它将蛋白质中的 O-连锁β-N-乙酰葡萄糖胺（O-GlcNAc）与丝氨酸和苏氨酸残基连接起来。大量研究表明，它对目标蛋白质的稳定性、活性和相互作用都有影响。O- 链接 N-乙酰葡糖胺转移酶（OGT）是催化 O-GlcNAc 修饰的关键酶，负责将 O-GlcNAc 添加到蛋白质中。OGT和O-GlcNAcylation在许多肿瘤中过度表达，与肿瘤的生长、侵袭、代谢、耐药性和免疫逃避密切相关。本综述阐述了 OGT 的生化功能，并总结了其在肿瘤中的作用和机制。以 OGT 为靶点是治疗人类恶性肿瘤的一种前景广阔的新方法。

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The roles of OGT and its mechanisms in cancer

O-linked-N-acetylglucosaminylation (O-GlcNAcylation) is a common and important post-translational modification (PTM) linking O-linked β-N-acetylglucosamine (O-GlcNAc) to serine and threonine residues in proteins. Extensive research indicates its impact on target protein stability, activity, and interactions. O-linked N-acetylglucosamine transferase (OGT) is a critical enzyme that catalyzes O-GlcNAc modification, responsible for adding O-GlcNAc to proteins. OGT and O-GlcNAcylation are overexpressed in many tumors and closely associated with tumor growth, invasion, metabolism, drug resistance, and immune evasion. This review delineates the biochemical functions of OGT and summarizes its effects and mechanisms in tumors. Targeting OGT presents a promising novel approach for treating human malignancies.

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来源期刊

Cell and Bioscience BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

10.70

自引率

0.00%

发文量

187

审稿时长

>12 weeks

期刊介绍： Cell and Bioscience, the official journal of the Society of Chinese Bioscientists in America, is an open access, peer-reviewed journal that encompasses all areas of life science research.