噬菌体的拯救：肠道微生物群的原位编辑

IF 14 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Microbiology Pub Date : 2024-09-13 DOI:10.1016/j.tim.2024.09.001

Charlotte Kamm, Chase L. Beisel

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引用次数: 0

摘要

肠道微生物群中有许多与我们的健康息息相关的细菌。然而，对这一群体进行基因改造仍然是一项重大挑战。Brödel等人迈出了关键的一步，他们利用噬菌体工程技术，在不传播基因货物的情况下有效地传递基因编辑器，从而高效地对小鼠肠道中的细菌进行编辑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Phages to the rescue: in situ editing of the gut microbiota

The gut microbiome contains numerous bacteria tied to our health. However, genetically modifying this community remains a major challenge. Brödel et al. take a critical step by engineering bacteriophages to efficiently deliver gene editors without propagation of the genetic cargo, efficiently introducing edits to bacteria residing in the mouse gut.

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来源期刊

Trends in Microbiology 生物-生化与分子生物学

CiteScore

25.30

自引率

0.60%

发文量

193

审稿时长

6-12 weeks

期刊介绍： Trends in Microbiology serves as a comprehensive, multidisciplinary forum for discussing various aspects of microbiology, spanning cell biology, immunology, genetics, evolution, virology, bacteriology, protozoology, and mycology. In the rapidly evolving field of microbiology, technological advancements, especially in genome sequencing, impact prokaryote biology from pathogens to extremophiles, influencing developments in drugs, vaccines, and industrial enzyme research.