通过经济模型了解奥氮平口服分散片(ODT)和奥氮平薄膜衣片作为一组药物与其他口服非典型抗精神病药物相比在摩洛哥治疗精神分裂症的成本效益

IF 3.6 3区 医学 Q1 PSYCHIATRY
Ahmed Tazi, Faouzi Errachidi, Dipesh Sonawane, Ghizlane Tahri, Sameer Rao, Suyog Mehta
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引用次数: 0

摘要

抗精神病药物是治疗精神分裂症的主要药物,其中奥氮平是治疗精神分裂症的有效药物。每个精神分裂症患者的经济成本都很高,其中抗精神病药物是一项主要支出。本研究旨在开发一个经济决策模型,比较精神分裂症患者的不同治疗方案,包括奥氮平口崩片(ODT)、奥氮平[ODT + 标准口服片剂(SOT)]、利培酮(ODT + SOT)和阿立哌唑(ODT + SOT),以确定其成本效益,从而优化摩洛哥的医疗资源分配。该研究利用已发表的医学文献和临床专家小组开发了一个决策分析模型。该模型旨在捕捉各种参数,如依从性水平、治疗中断、有无住院复发、质量调整生命年 (QALY)、治疗相关不良事件、医疗资源利用率以及相关成本。主要研究结果包括每次治疗的年度直接成本总额、QALYs 和每获得 1 QALY 的增量成本效益比 (ICER)。为考虑参数的不确定性,采用了单向和概率敏感性分析。根据模拟模型,与利培酮(分别为19%和62%)、阿立哌唑ODT(分别为26%和50%)和ODT+SOT剂型组相比,奥氮平ODT和ODT+SOT剂型组在住院复发率和患者病情保持稳定率(分别为11%和79%)方面是最有效的治疗方案。与利培酮(ICER:103,907 摩洛哥迪拉姆)和阿立哌唑(ICER:65,047 摩洛哥迪拉姆)的 ODT + SOT 组合组相比,奥氮平(ODT + SOT)治疗组具有成本效益。此外,与奥氮平 SOT(ICER:3921 摩洛哥迪拉姆)、利培酮 ODT(ICER:102298 摩洛哥迪拉姆)、利培酮 SOT(ICER:31088 摩洛哥迪拉姆)和阿立哌唑 ODT 或 SOT 制剂相比,奥氮平 ODT 具有成本效益。上述所有 ICER 均低于摩洛哥的支付意愿阈值 250,832.40 马其顿第纳尔。敏感性分析证实了研究结果的可靠性。该模型得出结论,在摩洛哥,与其他非典型抗精神病药物的 ODT 和 SOT 制剂相比,奥氮平 ODT 是最具成本效益的精神分裂症一线治疗方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An economic model to understand the cost-effectiveness of olanzapine orally dispersible tablets (ODT) and olanzapine film coated tablets as a group compared with other oral atypical antipsychotics for treating schizophrenia in Morocco
Antipsychotic medications are the primary treatment for schizophrenia, with olanzapine being an effective medication for schizophrenia. The economic cost for each individual with schizophrenia is high, with antipsychotic medication being a major expense. This study aims to develop an economic decision model that compares different treatment options for schizophrenia patients, including olanzapine Orally Dispersible Tablets (ODT), olanzapine [ODT + Standard Oral Tablet (SOT)], risperidone (ODT + SOT), and aripiprazole (ODT + SOT), to determine their cost-effectiveness with an objective to optimize healthcare resource allocation in Morocco. The study used published medical literature and a clinical expert panel to develop a decision analytic model. This model was designed to capture parameters such as adherence levels, treatment discontinuation, relapse with and without hospitalization, quality-adjusted life years (QALYs), treatment-related adverse events, healthcare resource utilization, and associated costs. The main outcomes of interest included the total annual direct cost per treatment, QALYs, and incremental cost-effectiveness ratio (ICER) per 1 QALY gained. One-way and probabilistic sensitivity analyses were employed to account for parameter uncertainty. According to the simulation model, the ODT and ODT + SOT as a group form of olanzapine was the most effective treatment option in terms of the lowest percentages of inpatient relapse, and patients who remained stable (11% and 79% respectively) than risperidone (19% and 62% respectively) and aripiprazole ODT (26% and 50% respectively) and ODT + SOT formulation groups. Olanzapine (ODT + SOT) therapy group was cost-effective when compared to the combined group of ODT + SOT forms of risperidone [ICER: Moroccan Dirham (MAD) 103,907], and aripiprazole (ICER: MAD 65,047). Additionally, olanzapine ODT was found to be cost-effective compared to olanzapine SOT with an ICER of MAD 3921, risperidone ODT with an ICER of MAD 1,02,298, risperidone SOT with an ICER of MAD 31,088, and aripiprazole ODT or SOT formulations. All the above ICERs fall under the willingness-to-pay threshold in Morocco of MAD 250,832.40. Sensitivity analyses confirmed the reliability of the findings. The model concluded that olanzapine ODT is the most cost-effective first-line treatment option for schizophrenia in Morocco when compared to other atypical antipsychotic medications in ODT and SOT formulations.
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来源期刊
CiteScore
6.60
自引率
2.70%
发文量
43
审稿时长
>12 weeks
期刊介绍: Annals of General Psychiatry considers manuscripts on all aspects of psychiatry, including neuroscience and psychological medicine. Both basic and clinical neuroscience contributions are encouraged. Annals of General Psychiatry emphasizes a biopsychosocial approach to illness and health and strongly supports and follows the principles of evidence-based medicine. As an open access journal, Annals of General Psychiatry facilitates the worldwide distribution of high quality psychiatry and mental health research. The journal considers submissions on a wide range of topics including, but not limited to, psychopharmacology, forensic psychiatry, psychotic disorders, psychiatric genetics, and mood and anxiety disorders.
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