Kadisha M. Culpepper, Jasmin B. Tindal, Natalie Y. Arnett
{"title":"反应时间对聚(木糖醇癸二酸酯)纳米粒子形成性能的影响","authors":"Kadisha M. Culpepper, Jasmin B. Tindal, Natalie Y. Arnett","doi":"10.1007/s10965-024-04114-0","DOIUrl":null,"url":null,"abstract":"<div><p>This research aims to correlate poly(xylitol sebacate) (PXS) nanoparticle formation via nanoprecipitation in the presence of Pluronic® F-127 to changes in polymer reaction times. PXS is successfully synthesized using xylitol and sebacic acid via melt polymerization (MP) at 10, 15 and 20 h. <sup>1</sup>H-NMR and <sup>13</sup>C-NMR confirmed the successful formation of PXS branched structures by the conversion of hydroxyl groups to acyl groups and ester bond formation in two different environments. The degree of branching and gel fraction increased with longer reaction time, which resulted in the crosslinking of PXS-MP-20H, deeming it insoluble for nanoparticle formation. Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) confirmed the thermal stability up to ~ 200 °C and an amorphous nature with subambient glass transition temperatures (T<sub>g</sub>). Among all polyesters, PXS-MP-15H showed best and only nanoparticle formation with average diameter size ranging from 112 to 132 nm for curcumin-loaded and unloaded respectively confirmed using dynamic light scattering (DLS). PXS-MP-15H nanoparticles had a curcumin encapsulation efficiency of 23.9%. This study shows the potential of highly branched polyesters such as PXS for use as drug carriers for targeted delivery.</p></div>","PeriodicalId":658,"journal":{"name":"Journal of Polymer Research","volume":"31 10","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of reaction time on the properties of poly(xylitol sebacate) for nanoparticle formation\",\"authors\":\"Kadisha M. Culpepper, Jasmin B. Tindal, Natalie Y. Arnett\",\"doi\":\"10.1007/s10965-024-04114-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>This research aims to correlate poly(xylitol sebacate) (PXS) nanoparticle formation via nanoprecipitation in the presence of Pluronic® F-127 to changes in polymer reaction times. PXS is successfully synthesized using xylitol and sebacic acid via melt polymerization (MP) at 10, 15 and 20 h. <sup>1</sup>H-NMR and <sup>13</sup>C-NMR confirmed the successful formation of PXS branched structures by the conversion of hydroxyl groups to acyl groups and ester bond formation in two different environments. The degree of branching and gel fraction increased with longer reaction time, which resulted in the crosslinking of PXS-MP-20H, deeming it insoluble for nanoparticle formation. Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) confirmed the thermal stability up to ~ 200 °C and an amorphous nature with subambient glass transition temperatures (T<sub>g</sub>). Among all polyesters, PXS-MP-15H showed best and only nanoparticle formation with average diameter size ranging from 112 to 132 nm for curcumin-loaded and unloaded respectively confirmed using dynamic light scattering (DLS). PXS-MP-15H nanoparticles had a curcumin encapsulation efficiency of 23.9%. This study shows the potential of highly branched polyesters such as PXS for use as drug carriers for targeted delivery.</p></div>\",\"PeriodicalId\":658,\"journal\":{\"name\":\"Journal of Polymer Research\",\"volume\":\"31 10\",\"pages\":\"\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2024-09-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Polymer Research\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10965-024-04114-0\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"POLYMER SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Polymer Research","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10965-024-04114-0","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
Effect of reaction time on the properties of poly(xylitol sebacate) for nanoparticle formation
This research aims to correlate poly(xylitol sebacate) (PXS) nanoparticle formation via nanoprecipitation in the presence of Pluronic® F-127 to changes in polymer reaction times. PXS is successfully synthesized using xylitol and sebacic acid via melt polymerization (MP) at 10, 15 and 20 h. 1H-NMR and 13C-NMR confirmed the successful formation of PXS branched structures by the conversion of hydroxyl groups to acyl groups and ester bond formation in two different environments. The degree of branching and gel fraction increased with longer reaction time, which resulted in the crosslinking of PXS-MP-20H, deeming it insoluble for nanoparticle formation. Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) confirmed the thermal stability up to ~ 200 °C and an amorphous nature with subambient glass transition temperatures (Tg). Among all polyesters, PXS-MP-15H showed best and only nanoparticle formation with average diameter size ranging from 112 to 132 nm for curcumin-loaded and unloaded respectively confirmed using dynamic light scattering (DLS). PXS-MP-15H nanoparticles had a curcumin encapsulation efficiency of 23.9%. This study shows the potential of highly branched polyesters such as PXS for use as drug carriers for targeted delivery.
期刊介绍：
Journal of Polymer Research provides a forum for the prompt publication of articles concerning the fundamental and applied research of polymers. Its great feature lies in the diversity of content which it encompasses, drawing together results from all aspects of polymer science and technology.
As polymer research is rapidly growing around the globe, the aim of this journal is to establish itself as a significant information tool not only for the international polymer researchers in academia but also for those working in industry. The scope of the journal covers a wide range of the highly interdisciplinary field of polymer science and technology, including:
polymer synthesis;
polymer reactions;
polymerization kinetics;
polymer physics;
morphology;
structure-property relationships;
polymer analysis and characterization;
physical and mechanical properties;
electrical and optical properties;
polymer processing and rheology;
application of polymers;
supramolecular science of polymers;
polymer composites.
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