用于生物传感和生物成像的光开关 AIE 活性超分子自组装体

IF 2.8 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2024-09-18 DOI:10.1002/ajoc.202400385

Fengfan Zhu, Xiao-Fang Hou, Juping Wang, Lei Bi, Jiancheng Zhou, Xu-Man Chen

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引用次数: 0

摘要

表现出聚集诱导发射（AIE）特性的可光开关荧光自组装体引起了广泛关注。由于对光反应、光异构化和光致发光激发所需的不同波长具有很强的适应性和响应性，这些荧光自组装体在空间、时间和多色性方面表现出多种发射行为。将有机光开关和 AIE 荧光团整合在一起，这些光致发光纳米组合体已被证明是一种有效的方法，可用于开发复杂的药物释放和细胞调控系统，并可通过光或其他刺激进行精确操控。这篇综述系统地总结了在多场景生物应用下可光电开关荧光自组装的最新进展。详细介绍了通过共价和非共价相互作用构建光开关 AIE 荧光团及其多模式调控，以及它们在生物传感、生物成像和药物治疗方面的生物学应用。

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Photoswitchable AIE-Active Supramolecular Self-Assemblies for Biosensing and Bioimaging

Photoswitchable fluorescent self-assemblies exhibiting aggregation-induced emission (AIE) properties have garnered widespread attention. Due to their great adaptiveness and responsiveness towards different wavelengths required by photoreaction, photo-isomerization, and photoluminescence excitation, these fluorescent self-assemblies show diverse emission behavior in a spatial, temporal, and polychromatic manner. Integrating organic photoswitches and AIE fluorophores, these photoluminescent nano-assemblies has been proven to be an effective approach, allowing the development of sophisticated systems for drug release and cell regulation that can be precisely manipulated through light or other stimuli. This review systematically encapsulates recent advances in photoswitchable fluorescent self-assemblies under multi-scenario biological applications. The construction of photoswitchable AIE fluorophores through covalent and non-covalent interactions and their multimodal regulation are detailed, along with their biological applications in biosensing, bioimaging, and drug therapy.

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.