海洋微生物中抗炎化合物的最新研究进展

IF 4.9 2区医学 Q1 CHEMISTRY, MEDICINAL

Marine Drugs Pub Date : 2024-09-18 DOI:10.3390/md22090424

Guihua Yang, Miaoping Lin, Kumaravel Kaliaperumal, Yaqi Lu, Xin Qi, Xiaodong Jiang, Xinya Xu, Chenghai Gao, Yonghong Liu, Xiaowei Luo

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引用次数: 0

摘要

人们发现，具有多样化结构的海洋微生物次级代谢产物是很有希望的抗炎先导化合物来源。本综述总结了过去三年（2021-2023 年）从海洋微生物中报道的抗炎天然产物的来源、化学结构和药理特性。约 252 种消炎化合物（包括 129 种新化合物）主要来自海洋真菌，它们在结构上分为多酮（51.2%）、萜类（21.0%）、生物碱（18.7%）、酰胺或肽（4.8%）和类固醇（4.3%）。本综述将阐明海洋微生物次生代谢物作为潜在抗炎先导化合物的发展情况，其在人类健康领域的临床应用前景广阔。

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Recent Advances in Anti-Inflammatory Compounds from Marine Microorganisms

Marine microbial secondary metabolites with diversified structures have been found as promising sources of anti-inflammatory lead compounds. This review summarizes the sources, chemical structures, and pharmacological properties of anti-inflammatory natural products reported from marine microorganisms in the past three years (2021–2023). Approximately 252 anti-inflammatory compounds, including 129 new ones, were predominantly obtained from marine fungi and they are structurally divided into polyketides (51.2%), terpenoids (21.0%), alkaloids (18.7%), amides or peptides (4.8%), and steroids (4.3%). This review will shed light on the development of marine microbial secondary metabolites as potential anti-inflammatory lead compounds with promising clinical applications in human health.

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来源期刊

Marine Drugs 医学-医药化学

CiteScore

9.60

自引率

14.80%

发文量

671

审稿时长

1 months

期刊介绍： Marine Drugs (ISSN 1660-3397) publishes reviews, regular research papers and short notes on the research, development and production of drugs from the sea. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible, particularly synthetic procedures and characterization information for bioactive compounds. There is no restriction on the length of the experimental section.