Sirtuins 1 抑制剂 EX527 通过下调细胞 FLICE 抑制蛋白，使 T 细胞白血病对死亡受体介导的细胞凋亡敏感

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL

ACS Applied Energy Materials Pub Date : 2024-09-17 DOI:10.1080/15384047.2024.2402588

Rongqi Guo, Yihui Wei, Yating Du, Luyue Liu, Haoqi Zhang, Ruiying Ren, Ruili Sun, Tingting Zhang, Xiwen Xiong, Lijun Zhao, Hongfei Wang, Xiaofang Guo, Xiaofei Zhu

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引用次数: 0

摘要

死亡受体介导的体外凋亡系统已被开发为临床肿瘤学中一种很有前景的治疗策略，如TRAIL疗法。然而，多项研究表明，...

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EX527, a sirtuins 1 inhibitor, sensitizes T-cell leukemia to death receptor-mediated apoptosis by downregulating cellular FLICE inhibitory protein

Death receptor-mediated extrinsic apoptosis system had been developed as a promising therapeutic strategy in clinical oncology, such as TRAIL therapy. However, multiple studies have demonstrated th...

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.