儿科低级别胶质瘤：经典病理学在综合诊断实践中的作用

IF 1.3 4区医学 Q4 CLINICAL NEUROLOGY

Child's Nervous System Pub Date : 2024-09-18 DOI:10.1007/s00381-024-06591-6

Thomas J. Stone, Ashirwad Merve, Fernanda Valerio, Shireena A. Yasin, Thomas S. Jacques

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引用次数: 0

摘要

低级别胶质瘤是导致儿童严重残疾且往往终身残疾的原因之一。病理学通过确定诊断、排除恶性肿瘤、预测预后和识别可靶向的基因改变，在这些肿瘤的治疗中发挥着关键作用。分子诊断重塑了病理学的领域，提出了传统组织学在其中扮演什么角色的问题。在这篇综述中，我们探讨了传统组织病理学对儿童低级别胶质瘤和胶质细胞瘤的分类和病理诊断，而全面的遗传学和表观遗传学特征描述则提供了更多的机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Paediatric low-grade glioma: the role of classical pathology in integrated diagnostic practice

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Paediatric low-grade glioma: the role of classical pathology in integrated diagnostic practice

Low-grade gliomas are a cause of severe and often life-long disability in children. Pathology plays a key role in their management by establishing the diagnosis, excluding malignant alternatives, predicting outcomes and identifying targetable genetic alterations. Molecular diagnosis has reshaped the terrain of pathology, raising the question of what part traditional histology plays. In this review, we consider the classification and pathological diagnosis of low-grade gliomas and glioneuronal tumours in children by traditional histopathology enhanced by the opportunities afforded by access to comprehensive genetic and epigenetic characterisation.

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来源期刊

Child's Nervous System 医学-临床神经学

CiteScore

3.00

自引率

7.10%

发文量

322

审稿时长

3 months

期刊介绍： The journal has been expanded to encompass all aspects of pediatric neurosciences concerning the developmental and acquired abnormalities of the nervous system and its coverings, functional disorders, epilepsy, spasticity, basic and clinical neuro-oncology, rehabilitation and trauma. Global pediatric neurosurgery is an additional field of interest that will be considered for publication in the journal.