Lei Shi, Meng-Ling Ruan, Bing-Bing Zhang, Guo-Xin Gong, Xue-Wu Li, Alainaa Refaie, Lv-Hui Sun, Zhang-Chao Deng
{"title":"膳食补充氧化锌量子点对肉鸡生长性能和肠道健康的影响","authors":"Lei Shi, Meng-Ling Ruan, Bing-Bing Zhang, Guo-Xin Gong, Xue-Wu Li, Alainaa Refaie, Lv-Hui Sun, Zhang-Chao Deng","doi":"10.1007/s12011-024-04371-6","DOIUrl":null,"url":null,"abstract":"<p>This study aims to investigate the effect of different levels of zinc oxide quantum dots (ZnO-QDs) on the growth performance and gut health in broilers. A total of 1125 1-day-old Ross 308 broilers were randomly divided into five groups with 15 replicates of 15 chicks each. The broilers were fed basal diets supplemented with 0, 40, 80, 120, or 160 mg Zn/kg as ZnO-QDs for 6 weeks. The results showed that dietary 80 and 120 mg Zn/kg ZnO-QD supplementation increased (<i>P</i> < 0.05) average daily gain (1.4–1.7%) and reduced feed conversion ratio (1.3%) compared to the basal diet group during various experimental periods. Meanwhile, 80 mg Zn/kg ZnO-QD supplementation increased (<i>P</i> < 0.05) trypsin activity (25.4%), villus height, and the ratio of villus height to crypt depth in the jejunum. Moreover, 80 mg Zn/kg ZnO-QD supplementation increased (<i>P</i> < 0.05) the activities of glutathione reductase (47.7%) and superoxide dismutase (30.9%), while 120 mg Zn/kg ZnO-QD supplementation decreased (<i>P</i> < 0.05) glutathione peroxidase activity (27.1%) in the jejunum. Furthermore, 40 mg Zn/kg ZnO-QD supplementation down-regulated (<i>P</i> < 0.05) the expression of genes; <i>interleukin-2</i>, transforming growth factor β (<i>TGF-β</i>), <i>Cathelicidin-1</i>, <i>Cathelicidin-2</i>, <i>Cathelicidin-3</i>, and <i>Occludin</i>, while 80–160 mg Zn/kg ZnO-QD supplementation up-regulated (<i>P</i> < 0.05) <i>Claudin-2</i> expression in the jejunum. In conclusion, dietary ZnO-QD supplementation improved growth performance of broilers potentially by enhancing their intestinal health status. Based on nonlinear regression analysis, the appropriate level of ZnO-QD supplementation would be from 98.2 to 102.5 mg Zn/kg.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of Dietary Supplementation of Zinc Oxide Quantum Dots on Growth Performance and Gut Health in Broilers\",\"authors\":\"Lei Shi, Meng-Ling Ruan, Bing-Bing Zhang, Guo-Xin Gong, Xue-Wu Li, Alainaa Refaie, Lv-Hui Sun, Zhang-Chao Deng\",\"doi\":\"10.1007/s12011-024-04371-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>This study aims to investigate the effect of different levels of zinc oxide quantum dots (ZnO-QDs) on the growth performance and gut health in broilers. A total of 1125 1-day-old Ross 308 broilers were randomly divided into five groups with 15 replicates of 15 chicks each. The broilers were fed basal diets supplemented with 0, 40, 80, 120, or 160 mg Zn/kg as ZnO-QDs for 6 weeks. The results showed that dietary 80 and 120 mg Zn/kg ZnO-QD supplementation increased (<i>P</i> < 0.05) average daily gain (1.4–1.7%) and reduced feed conversion ratio (1.3%) compared to the basal diet group during various experimental periods. Meanwhile, 80 mg Zn/kg ZnO-QD supplementation increased (<i>P</i> < 0.05) trypsin activity (25.4%), villus height, and the ratio of villus height to crypt depth in the jejunum. Moreover, 80 mg Zn/kg ZnO-QD supplementation increased (<i>P</i> < 0.05) the activities of glutathione reductase (47.7%) and superoxide dismutase (30.9%), while 120 mg Zn/kg ZnO-QD supplementation decreased (<i>P</i> < 0.05) glutathione peroxidase activity (27.1%) in the jejunum. Furthermore, 40 mg Zn/kg ZnO-QD supplementation down-regulated (<i>P</i> < 0.05) the expression of genes; <i>interleukin-2</i>, transforming growth factor β (<i>TGF-β</i>), <i>Cathelicidin-1</i>, <i>Cathelicidin-2</i>, <i>Cathelicidin-3</i>, and <i>Occludin</i>, while 80–160 mg Zn/kg ZnO-QD supplementation up-regulated (<i>P</i> < 0.05) <i>Claudin-2</i> expression in the jejunum. In conclusion, dietary ZnO-QD supplementation improved growth performance of broilers potentially by enhancing their intestinal health status. Based on nonlinear regression analysis, the appropriate level of ZnO-QD supplementation would be from 98.2 to 102.5 mg Zn/kg.</p>\",\"PeriodicalId\":8917,\"journal\":{\"name\":\"Biological Trace Element Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2024-09-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biological Trace Element Research\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1007/s12011-024-04371-6\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biological Trace Element Research","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s12011-024-04371-6","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Effects of Dietary Supplementation of Zinc Oxide Quantum Dots on Growth Performance and Gut Health in Broilers
This study aims to investigate the effect of different levels of zinc oxide quantum dots (ZnO-QDs) on the growth performance and gut health in broilers. A total of 1125 1-day-old Ross 308 broilers were randomly divided into five groups with 15 replicates of 15 chicks each. The broilers were fed basal diets supplemented with 0, 40, 80, 120, or 160 mg Zn/kg as ZnO-QDs for 6 weeks. The results showed that dietary 80 and 120 mg Zn/kg ZnO-QD supplementation increased (P < 0.05) average daily gain (1.4–1.7%) and reduced feed conversion ratio (1.3%) compared to the basal diet group during various experimental periods. Meanwhile, 80 mg Zn/kg ZnO-QD supplementation increased (P < 0.05) trypsin activity (25.4%), villus height, and the ratio of villus height to crypt depth in the jejunum. Moreover, 80 mg Zn/kg ZnO-QD supplementation increased (P < 0.05) the activities of glutathione reductase (47.7%) and superoxide dismutase (30.9%), while 120 mg Zn/kg ZnO-QD supplementation decreased (P < 0.05) glutathione peroxidase activity (27.1%) in the jejunum. Furthermore, 40 mg Zn/kg ZnO-QD supplementation down-regulated (P < 0.05) the expression of genes; interleukin-2, transforming growth factor β (TGF-β), Cathelicidin-1, Cathelicidin-2, Cathelicidin-3, and Occludin, while 80–160 mg Zn/kg ZnO-QD supplementation up-regulated (P < 0.05) Claudin-2 expression in the jejunum. In conclusion, dietary ZnO-QD supplementation improved growth performance of broilers potentially by enhancing their intestinal health status. Based on nonlinear regression analysis, the appropriate level of ZnO-QD supplementation would be from 98.2 to 102.5 mg Zn/kg.
期刊介绍：
Biological Trace Element Research provides a much-needed central forum for the emergent, interdisciplinary field of research on the biological, environmental, and biomedical roles of trace elements. Rather than confine itself to biochemistry, the journal emphasizes the integrative aspects of trace metal research in all appropriate fields, publishing human and animal nutritional studies devoted to the fundamental chemistry and biochemistry at issue as well as to the elucidation of the relevant aspects of preventive medicine, epidemiology, clinical chemistry, agriculture, endocrinology, animal science, pharmacology, microbiology, toxicology, virology, marine biology, sensory physiology, developmental biology, and related fields.
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