通过检测脂滴进行脂肪肝成像的荧光探针的最新进展

IF 6.1 3区医学 Q1 MATERIALS SCIENCE, BIOMATERIALS

Journal of Materials Chemistry B Pub Date : 2024-09-04 DOI:10.1039/d4tb01741b

Long He, Hang Li, Yao Tang, Tian-Bing Ren, Lin Yuan

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引用次数: 0

摘要

脂肪肝是世界范围内的一个主要健康问题，与疾病过程中能量储存细胞器--脂滴（LDs）的异常积累和改变密切相关。具有优异光学性能、高灵敏度/选择性和实时监测功能的荧光探针已成为用于脂肪肝诊断的一种极具吸引力的 LDs 检测工具。在这篇综述中，我们总结了基于不同反应机制的各种探针，它们利用不同的激发成像模式和发射波长（包括可见光到近红外、双/三光子和第二近红外区域）对脂肪肝过程中的低密度脂蛋白进行成像。此外，还讨论了与所报道的脂滴探针有关的未来发展前景和障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Recent advances in fluorescent probes for fatty liver imaging by detecting lipid droplets

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Recent advances in fluorescent probes for fatty liver imaging by detecting lipid droplets

Fatty liver, a major health problem worldwide, is closely associated with aberrant accumulation and alteration of energy storage organelles, lipid droplets (LDs), in the disease process. Fluorescent probes with excellent optical performance, high sensitivity/selectivity and real-time monitoring have emerged as an attractive tool for the detection of LDs used in the diagnosis of fatty liver. In this review, we summarize various probes based on different response mechanisms to image LDs in the fatty liver process using different excitation imaging modes and emission wavelengths, including the visible to the near-infrared, two/three-photon, and the second near-infrared region. The perspectives and barriers associated with the reported lipid droplet (LD) probes for future development are also discussed.

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来源期刊

Journal of Materials Chemistry B MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

11.50

自引率

4.30%

发文量

866

期刊介绍： Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive： Antifouling coatings Biocompatible materials Bioelectronics Bioimaging Biomimetics Biomineralisation Bionics Biosensors Diagnostics Drug delivery Gene delivery Immunobiology Nanomedicine Regenerative medicine & Tissue engineering Scaffolds Soft robotics Stem cells Therapeutic devices