Yuewei Zhao, Xvelian Li, Yan Zhou, Xiaoting Tian, Yayou Miao, Jiayi Wang, Lin Huang, Fanyu Meng
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引用次数: 0
摘要
DNA 计算利用 DNA 执行布尔逻辑运算,被认为是下一代分子计算机中最有前途的候选者之一。近几十年来,DNA 计算因其强大的可编程和并行计算能力而受到广泛关注,并在智能生物分析方面展现出巨大潜力。本综述总结了 DNA 逻辑系统及其生物医学应用的最新进展。首先,它介绍了基于各种材料(如功能 DNA 序列、纳米材料和三维 DNA 纳米结构)的最新 DNA 逻辑系统。报告总结了推动 DNA 计算的材料创新,重点介绍了新型分子反应以及效率、灵敏度和选择性等分析性能指标。随后,报告概述了基于 DNA 计算的多生物标记分析在细胞成像、临床诊断和疾病治疗方面的生物医学应用。此外,报告还讨论了 DNA 计算发展面临的现有挑战和未来研究方向。
Advancements in DNA computing: exploring DNA logic systems and their biomedical applications
DNA computing is regarded as one of the most promising candidates for the next generation of molecular computers, utilizing DNA to execute Boolean logic operations. In recent decades, DNA computing has garnered widespread attention due to its powerful programmable and parallel computing capabilities, demonstrating significant potential in intelligent biological analysis. This review summarizes the latest advancements in DNA logic systems and their biomedical applications. Firstly, it introduces recent DNA logic systems based on various materials such as functional DNA sequences, nanomaterials, and three-dimensional DNA nanostructures. The material innovations driving DNA computing have been summarized, highlighting novel molecular reactions and analytical performance metrics like efficiency, sensitivity, and selectivity. Subsequently, it outlines the biomedical applications of DNA computing-based multi-biomarker analysis in cellular imaging, clinical diagnosis, and disease treatment. Additionally, it discusses the existing challenges and future research directions for the development of DNA computing.
期刊介绍:
Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive:
Antifouling coatings
Biocompatible materials
Bioelectronics
Bioimaging
Biomimetics
Biomineralisation
Bionics
Biosensors
Diagnostics
Drug delivery
Gene delivery
Immunobiology
Nanomedicine
Regenerative medicine & Tissue engineering
Scaffolds
Soft robotics
Stem cells
Therapeutic devices