糖尿病大血管病变中的微RNA

IF 8.5 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Diabetology Pub Date : 2024-09-16 DOI:10.1186/s12933-024-02405-w

Guocheng Rao, Boqiang Peng, Guixiang Zhang, Xianghui Fu, Jingyan Tian, Yan Tian

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引用次数: 0

摘要

糖尿病大血管病变是全球糖尿病相关死亡的主要原因。遗传和环境因素通过多种潜在的分子机制，共同作用于糖尿病大血管病变的发病机制。微小核糖核酸（miRNA）是一类以功能多样性和表达特异性著称的非编码核糖核酸，它们在糖尿病和糖尿病大血管病变的发生和发展过程中的作用日益得到认可。在这篇综述中，我们将描述 miRNAs 的生物发生，并总结它们在糖尿病大血管病变（包括动脉粥样硬化、外周动脉疾病、冠状动脉疾病和脑血管疾病）中的功能，预计这将为 miRNAs 在基础、转化和临床研究中的未来前景提供新的见解，最终推动糖尿病大血管病变的诊断、预防和治疗。

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MicroRNAs in diabetic macroangiopathy

Diabetic macroangiopathy is a leading cause of diabetes-related mortality worldwide. Both genetic and environmental factors, through a multitude of underlying molecular mechanisms, contribute to the pathogenesis of diabetic macroangiopathy. MicroRNAs (miRNAs), a class of non-coding RNAs known for their functional diversity and expression specificity, are increasingly recognized for their roles in the initiation and progression of diabetes and diabetic macroangiopathy. In this review, we will describe the biogenesis of miRNAs, and summarize their functions in diabetic macroangiopathy, including atherosclerosis, peripheral artery disease, coronary artery disease, and cerebrovascular disease, which are anticipated to provide new insights into future perspectives of miRNAs in basic, translational and clinical research, ultimately advancing the diagnosis, prevention, and treatment of diabetic macroangiopathy.

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来源期刊

Cardiovascular Diabetology 医学-内分泌学与代谢

CiteScore

12.30

自引率

15.10%

发文量

240

审稿时长

1 months

期刊介绍： Cardiovascular Diabetology is a journal that welcomes manuscripts exploring various aspects of the relationship between diabetes, cardiovascular health, and the metabolic syndrome. We invite submissions related to clinical studies, genetic investigations, experimental research, pharmacological studies, epidemiological analyses, and molecular biology research in this field.