不同病程的 2 型糖尿病患者血清阿司匹林与代谢特征、并发症之间的关联分析

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2024-09-14 DOI:10.1111/jdi.14313

Lijing Ma, Zhengqian Wang, Li Sun, Mina Li, Qianqian Wu, Ming Liu, Minggang Xu, Guoliang Shi, Jianhong Yin, Yan Wang, Linxin Xu

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引用次数: 0

摘要

材料与方法本研究从山西省东南部的社区卫生服务中心招募了436名2型糖尿病患者。根据糖尿病病程将所有患者分为两组：糖尿病病程≤5年组（132人）和糖尿病病程≥10年组（304人）。采集空腹血样并检测血清asprosin。结果两组患者的胰岛素含量相当。糖尿病病程≤5 年组的阿司匹林与收缩压（SBP）、甘油三酯、肌酐、血清尿酸和低密度脂蛋白胆固醇呈正相关（P < 0.05）。在糖尿病病程≥10 年组，阿司匹林与 SBP、舒张压、体重指数、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、肌酐、血清尿酸、空腹血浆葡萄糖和糖化血红蛋白独立相关（P < 0.05）。阿司匹林与丙氨酸氨基转移酶和估计肾小球滤过率相关（P< 0.05）。多元线性回归分析发现，在糖尿病病程≤5年的人群中，SBP和舒张压是与血清asprosin相关的独立因素（P <0.05）。结论糖尿病病程≥10年者血清rosin显著升高，糖化血红蛋白、血压和估计肾小球滤过率是长期2型糖尿病的独立危险因素。

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Association analysis between serum asprosin and metabolic characteristics, Complications in type 2 diabetic patients with different durations

Aims/IntroductionTo investigated the association between serum asprosin and metabolic characteristics in type 2 diabetes mellitus patients with different durations.Materials and MethodsA total of 436 patients with type 2 diabetes mellitus were enrolled in this study from the community health service center in southeastern Shanxi Province. All the patients were divided into two groups according to their diabetes duration: diabetes duration ≤5 years group (n = 132) and diabetes duration ≥10 years group (n = 304). Fasting blood samples were gathered and serum asprosin was tested. Pearson/Spearman correlation analysis was carried out.ResultsAsprosin was comparable between the two groups. Asprosin was positively correlated with systolic blood pressure (SBP), triglycerides, creatinine, serum uric acid and low‐density lipoprotein cholesterol in the diabetes duration ≤5 years group (P < 0.05). In the diabetes duration ≥10 years group, asprosin was independently correlated with SBP, diastolic blood pressure, body mass index, total cholesterol, triglycerides, low‐density lipoprotein cholesterol, creatinine, serum uric acid, fasting plasma glucose and glycosylated hemoglobin (P < 0.05). Asprosin was associated with alanine aminotransferase and estimated glomerular filtration rate (P < 0.05). Multiple linear regression analysis found that SBP and diastolic blood pressure is an independent factor related to serum asprosin in the group with diabetes duration ≤5 years (P < 0.05). Fasting plasma glucose, SBP, total cholesterol and serum uric acid is an independent factor related to serum asprosin in the group with diabetes duration ≥10 years (P < 0.05).ConclusionsSerum asprosin was significantly increased in the group with diabetes duration ≥10 years, and glycosylated hemoglobin, blood pressure and estimated glomerular filtration rate were independent risk factors in long‐duration type 2 diabetes mellitus.

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来源期刊

Journal of Diabetes Investigation Medicine-Internal Medicine

自引率

9.40%

发文量

218

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).