一只免疫力低下的英国斯普林格猎犬患上了由灰锈病菌引起的噬菌体病

IF 0.3 Q4 VETERINARY SCIENCES
Erin Brennan, Theofanis Liatis, Sian‐Marie Frosini, Elizabeth Johnson, Ross Bond
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引用次数: 0

摘要

一只 10 岁的雄性农场春犬出现亚急性进行性左侧中央前庭症状,被诊断为不明原因的脑膜脑炎。患者接受了泼尼松龙(2 毫克/千克/天,口服)、环孢素(5 毫克/千克,口服,一天两次)和一次阿糖胞苷输注(200 毫克/平方米)。六周后,神经系统症状缓解,但四肢、躯干和面部出现多发性皮肤结节。病变部位排出深色脓性物质,没有组织颗粒。分离出一种 "丝状真菌",但未经鉴定就丢弃了。从结节中抽出的吸液显示出色素沉着、有隔膜的真菌菌丝,对吸液进行培养后发现了灰褐斑曲霉(Trematosphaeria grisea)。伊曲康唑(5 毫克/千克,每天一次)和免疫抑制剂的逐渐减量导致结节性病变在 4 个月内消退,神经系统没有复发。在开始使用伊曲康唑 8 个月后,出现了短暂的真菌肉芽肿。使用免疫抑制剂 15 个月后停药,神经系统未复发。8 周后,即皮肤病最后一次复发 5 个月后,停用了伊曲康唑。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Phaeohyphomycosis caused by Trematosphaeria grisea in an immunocompromised English springer spaniel
A 10‐year‐old, male, farm‐based springer spaniel that presented with subacute progressive left‐sided central vestibular signs was diagnosed with meningoencephalitis of unknown origin. The patient received prednisolone (2 mg/kg/day orally), ciclosporin (5 mg/kg orally twice a day) and a single infusion of cytarabine (200 mg/m2). Six weeks later, neurological signs had resolved, but multiple cutaneous nodules developed on the limbs, trunk and face. Lesions discharged a dark purulent material without tissue grains. A ‘filamentous fungus’ was isolated, but discarded without identification. Aspirates from nodules showed pigmented, septate fungal hyphae, and culture of aspirates yielded Trematosphaeria grisea. Itraconazole (5 mg/kg once a day) and gradual tapering of immunosuppressive drugs led to resolution of nodular lesions over 4 months without neurological relapse. A fungal granuloma developed transiently 8 months after starting itraconazole. Immunosuppressive drugs were stopped 15 months after introduction without neurological relapse. Itraconazole was withdrawn 8 weeks later, 5 months after last relapse of skin disease.
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来源期刊
Veterinary Record Case Reports
Veterinary Record Case Reports Veterinary-Veterinary (all)
CiteScore
0.50
自引率
33.30%
发文量
266
期刊介绍: Vet Record Case Reports is an online resource that publishes articles in all fields of veterinary medicine and surgery so that veterinary professionals, researchers and others can easily find important information on both common and rare conditions. Articles may be about a single animal, herd, flock or other group of animals managed together. Common cases that present a diagnostic, ethical or management challenge, or that highlight aspects of mechanisms of injury, pharmacology or histopathology are deemed of particular educational value. All articles are peer reviewed and copy edited before publication.
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