中国阜阳非结核分枝杆菌肺疾病患者的临床特征：回顾性研究

IF 2.9 3区医学 Q2 INFECTIOUS DISEASES

Infection and Drug Resistance Pub Date : 2024-09-14 DOI:10.2147/idr.s475652

Xiaowu Wang, Tuantuan Li, Yan Liu, Yilang Zhu, Lichang Chen, Yong Gao

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引用次数: 0

摘要

目的：回顾性分析富阳区传染病定点医院连续报告的非结核分枝杆菌（NTM）肺疾病患者，以确定这些患者的临床特征：本研究招募了2018年1月至2023年5月期间中国富阳地区的234名NTM肺部疾病患者。数据来自电子病历。对NTM菌株组成和NTM肺病的临床特征进行回顾性分析：73例（31.20%）患者既往有肺结核或肺结核接触史和支气管扩张。混合型 NTM 感染占 12.39%。在 132 名患者（49.62%）中检测到了细胞内分枝杆菌菌株。研究发现，女性更多地受到禽分枝杆菌感染的影响，而男性则更多地受到脓肿分枝杆菌感染的影响。禽分枝杆菌（34.21%）和脓肿分枝杆菌（33.33%）菌株最常见于曾患结核病或有结核病接触史的人。在呼吸道相关疾病中，支气管扩张患者的分枝杆菌分离率最高（55.36%）。女性易患支气管扩张症（P < 0.01）。男性的单核-淋巴细胞比值（MLR）中位数高于女性（P < 0.01）。有肺结核或肺结核接触史的患者血清白蛋白（ALB）水平低于无肺结核接触史的患者（P = 0.034）。有结核病或结核病接触史的患者的预后营养指数（PNI）低于无结核病史的患者（P = 0.021）。NTM肺病患者的治疗效果不佳：结论：该疾病的临床症状没有物种特异性。结论：非结核分枝杆菌肺部疾病的临床症状没有物种特异性。既往结核病史或结核病接触史大大增加了罹患 NTM 的风险：NTM、临床症状、结核接触史、支气管扩张症

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Clinical Characteristics of Patients with Nontuberculous Mycobacterium Pulmonary Disease in Fuyang, China: A Retrospective Study

Objective: We retrospectively review consecutive patients with nontuberculous mycobacterium (NTM) pulmonary disease reported from a designated hospital for infectious diseases in the Fuyang district of China to determine the clinical characteristics of these patients.
Methods: This research enrolled 234 patients with NTM pulmonary disease between January 2018 and May 2023 in the Fuyang district of China. Data were collected from the electronic medical records. The NTM strain composition and clinical characteristics of NTM pulmonary disease were retrospectively analyzed.
Results: 73 (31.20%) patients had previous tuberculosis (TB) or TB exposure history and bronchiectasis. Mixed NTM infection accounted for 12.39%. Mycobacterium intracellulare strain was detected in 132 patients (49.62%). Women were found to be more affected by Mycobacterium avium infection, and men by Mycobacterium abscessus infection. Mycobacterium avium (34.21%) and Mycobacterium abscessus (33.33%) strains were most common in people with previous TB or TB exposure history. Among respiratory tract-related diseases, patients with bronchiectasis had the highest isolation rate of Mycobacterium avium (55.36%). Women were susceptible to bronchiectasis (P < 0.01). The median of mononuclear-to-lymphocyte ratio (MLR) was higher in men than in women (P < 0.01). The serum albumin (ALB) level was lower in patients with TB or TB exposure history than in those without TB history (P = 0.034). The prognostic nutritional index (PNI) was lower in patients with TB or TB exposure history than in those without tuberculosis history (P = 0.021). Patients with NTM lung disease were poorly treated.
Conclusion: Clinical symptoms of the disease were not species-specific. Mycobacterium intracellulare and Mycobacterium avium strains were predominant in the Fuyang district of China. Previous TB or TB exposure history immensely enhanced the risk of NTM disease.

Keywords: NTM, clinical symptoms, tuberculosis exposure history, bronchiectasis

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来源期刊

Infection and Drug Resistance Medicine-Pharmacology (medical)

CiteScore

5.60

自引率

7.70%

发文量

826

审稿时长

16 weeks

期刊介绍： About Journal Editors Peer Reviewers Articles Article Publishing Charges Aims and Scope Call For Papers ISSN: 1178-6973 Editor-in-Chief: Professor Suresh Antony An international, peer-reviewed, open access journal that focuses on the optimal treatment of infection (bacterial, fungal and viral) and the development and institution of preventative strategies to minimize the development and spread of resistance.