皮肤核酸疗法。

IF 8.3 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces Pub Date : 2024-09-13 DOI:10.1016/j.jid.2024.07.029

Andreas C Chai,Daniel J Siegwart,Richard C Wang

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引用次数: 0

摘要

测序技术的进步有助于确定许多遗传性皮肤病的基因和发病机制。虽然针对其他器官疾病的核酸靶向疗法已开始在患者身上应用，但针对皮肤病的精确疗法的目标尚未实现。首先，我们回顾了当前和新兴的基于核酸的基因编辑和传递模式。其次，回顾了目前和新兴的病毒和纳米粒子载体用于传递基因疗法。最后，重点介绍了可从核酸疗法中获得最佳疗效的特定皮肤病。通过采用最新技术和解决与皮肤生物学相关的特定障碍，核酸疗法有可能彻底改变皮肤病患者的治疗方法。

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Nucleic Acid Therapy for the Skin.

Advances in sequencing technologies have facilitated the identification of the genes and mechanisms for many inherited skin diseases. Although targeted nucleic acid therapeutics for diseases in other organs have begun to be deployed in patients, the goal of precise therapeutics for skin diseases has not yet been realized. First, we review the current and emerging nucleic acid-based gene-editing and delivery modalities. Next, current and emerging viral and nanoparticle vehicles for the delivery of gene therapies are reviewed. Finally, specific skin diseases that could benefit optimally from nucleic acid therapies are highlighted. By adopting the latest technologies and addressing specific barriers related to skin biology, nucleic acid therapeutics have the potential to revolutionize treatments for patients with skin disease.

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来源期刊

ACS Applied Materials & Interfaces 工程技术-材料科学：综合

CiteScore

16.00

自引率

6.30%

发文量

4978

审稿时长

1.8 months

期刊介绍： ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.