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新型人源化抗PcrV单克隆抗体COT-143通过抑制III型分泌系统的毒素转运，保护小鼠免受致命铜绿假单胞菌感染

IF 4.1 2区 医学 Q2 MICROBIOLOGY
Antimicrobial Agents and Chemotherapy Pub Date : 2024-09-13 DOI:10.1128/aac.00694-24
Shunsuke NumataTakafumi HaraMasaaki IzawaYosuke OkunoYasuhiko SatoShoji YamaneHideki MakiTakafumi SatoYoshinori Yamano1Laboratory for Drug Discovery and Disease Research, Shionogi & Co., Ltd., Toyonaka, Japan2Shionogi TechnoAdvance Research & Co., Ltd., Toyonaka, Japan3Business Development Department, Shionogi & Co., Ltd., Toyonaka, JapanJames E. Leggett
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抗菌剂与化疗》，印刷版前。
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Novel humanized anti-PcrV monoclonal antibody COT-143 protects mice from lethal Pseudomonas aeruginosa infection via inhibition of toxin translocation by the type III secretion system
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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来源期刊
Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy 医学-微生物学
CiteScore
10.00
自引率
8.20%
发文量
762
审稿时长
3 months
期刊介绍： Antimicrobial Agents and Chemotherapy (AAC) features interdisciplinary studies that build our understanding of the underlying mechanisms and therapeutic applications of antimicrobial and antiparasitic agents and chemotherapy.
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